null
SMILES C[C@@H]1C[C@H]1C(=O)N1CCN(C[C@H]1C)c1cnc(C#N)c(n1)-c1cnn(C)c1
InChI Key InChIKey=GXEXIUKEWXZCEF-UMVBOHGHSA-N
PDB links: 1 PDB ID matches this monomer.
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 275 hits for monomerid = 50537742
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition Protein kinase C gammaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Protein kinase C beta 1More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Tested in vitro for the ability to inhibit HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
TargetNuclear receptor subfamily 1 group I member 2(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataEC50: >3.00E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 884nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 945nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 5.37E+3nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 1.37E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.38E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 2.35E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 2.54E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
Affinity DataIC50: 2.56E+4nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 2.61E+4nMAssay Description:Inhibitory activity against cytosolic c-SrcMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of the fibroblast growth factor receptor (FGFR1)More data for this Ligand-Target Pair
Affinity DataIC50: 2.81E+4nMAssay Description:Inhibition of recombinant full length human His-tagged GSK3beta expressed in baculovirus expression system using serine/threonine-9 peptide as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.91E+4nMAssay Description:Inhibition of recombinant full length human His-tagged RSK2 expressed in baculovirus expression system using serine/threonine-6 peptide as substrate ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 5(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 3.04E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged KHS1 expressed in baculovirus expression system using serine/threonine-7 peptide as substrate ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPHA1 cytoplasmic domain (568 to 976 residues) expressed in baculovirus expression system using Tyr 02 as ...More data for this Ligand-Target Pair
Affinity DataIC50: 3.47E+4nMAssay Description:Inhibition of recombinant full length human GST-tagged GRK4 expressed in baculovirus expression system using serine/threonine-16 peptide as substrate...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of full length recombinant GST-tagged human YES1 expressed in baculovirus expression system using tyr 02 peptide as substrate after 1 hr i...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of recombinant human His-tagged KDR (789 to 1356 residues) expressed in baculovirus expression system using Tyr1 as substrate incubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 3.76E+4nMAssay Description:Inhibition of recombinant full length N-terminal GST-tagged human HCK expressed in baculovirus expression system using Tyr 02 as substrate after 1 hr...More data for this Ligand-Target Pair
Affinity DataIC50: 3.77E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPHB1 catalytic domain expressed in baculovirus expression system using tyrosine-2 peptide as substrate in...More data for this Ligand-Target Pair
Affinity DataIC50: 3.96E+4nMAssay Description:Inhibition of recombinant full length human His-tagged BTK expressed in baculovirus expression system using tyrosine-2 peptide as substrate incubated...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 4.05E+4nMAssay Description:Inhibition of recombinant GST-tagged human PIK3C2B catalytic domain expressed in baculovirus expression system using PI as substrate after 1 hr in pr...More data for this Ligand-Target Pair
TargetTestis-specific serine/threonine-protein kinase 1(Homo sapiens (Human))
Merck & Co.
Curated by ChEMBL
Merck & Co.
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant full length human His-tagged TSSK1 expressed in baculovirus expression system using serine/threonine-4 peptide as substrate...More data for this Ligand-Target Pair