null

SMILES CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O

InChI Key InChIKey=OUCUNVKXSOPBBS-OAHLLOKOSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50544205   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of cKit (unknown origin) by functional based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human cKit (544 to end residues) expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human wild type partial length TAK1 (1 to 303 residues) expressed in mammalian expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center

Curated by ChEMBL
LigandPNGBDBM50544205(CHEMBL4641090)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542S4MPubMed