null
SMILES CC(C)Nc1cc(Nc2ccn3nccc3n2)ncc1C(=O)NC[C@@H](F)C(C)(C)O
InChI Key InChIKey=OUCUNVKXSOPBBS-OAHLLOKOSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 7 hits for monomerid = 50544205
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of IRAK4 (unknown origin) using FL-IPTSPITTTYFFFKKK peptide and ATP as substrate incubated for 60 mins by fluorescence based caliper assayMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation and meas...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as inhibition of LTA-induced IL-6 production preincubated for 30 mins followed by LTA-stimulation a...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of cKit (unknown origin) by functional based assayMore data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human cKit (544 to end residues) expressed in baculovirus infected Sf21 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 190nMAssay Description:Inhibition of human wild type partial length TAK1 (1 to 303 residues) expressed in mammalian expression systemMore data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Biocon Bristol Myers Squibb Research Center
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human wild type partial length TNIK (D4-K311 residues) expressed in bacterial expression systemMore data for this Ligand-Target Pair