null

SMILES CC12CC(C1)(C2)C1=C(CN2CCN(CC2)c2ccc(cc2)C(=O)NS(=O)(=O)c2ccc(N[C@H](CCN3CCC(O)CC3)CSc3ccccc3)c(c2)S(=O)(=O)C(F)(F)F)CC(C)(C)CC1

InChI Key

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 552931   

TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K4G5TUS Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown in parall...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q29K4G5TUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7ZW9US Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7ZW9US Patent
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent
TargetBcl-2-like protein 1(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7ZW9US Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent
TargetBcl2-associated agonist of cell death(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataKd:  55nMAssay Description:Table 1: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was assessed using the Bcl2scan™ platform: T7 phage strains displaying BCL2 proteins were grown ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2QR51BHUS Patent
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))TBA
LigandPNGBDBM552931((R)-4-(4-((5,5-dimethyl-2-(3-methylbicyclo[1.1.1]p...)copy SMILES
Affinity DataIC50: 10nMAssay Description:Table 2: Binding to Bcl-2 proteins Bcl-2, and Bcl-XL was also assessed using an HTRF assay. Background: FAM-Bak/Bad binds to surface pocket of the Bc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HD7ZW9US Patent