null

SMILES CC(C)n1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2ccc1=O

InChI Key InChIKey=FZMILJWYZFDXTP-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6274   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 675nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 270nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(pro...)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 12 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B00N4PubMed