null

SMILES CC(C)c1ccc(Nc2nccc(n2)-c2cnn3ncccc23)cc1

InChI Key InChIKey=UODXTGBFBIFREQ-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 8131   

TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.99E+3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of CDK4 by radioactive glutathione plate-binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GZNPubMed
LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:The compound was evaluated for its relative binding affinity against mutant N131A scytalone dehydratase; Relative KiMore data for this Ligand-Target Pair
In DepthDetails
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human CDK2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GZNPubMed
TargetCyclin-K(Homo sapiens (Human))TBA
LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Ability to displace [3H]glycine from strychnine-insensitive glycine receptorMore data for this Ligand-Target Pair
In DepthDetails
TargetCyclin-C(Homo sapiens (Human))TBA
LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:The compound was evaluated for its relative binding affinity against mutant Y50F scytalone dehydratase; Relative KiMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8131(N-(4-Isopropylphenyl)-4-pyrazolo[1,5-b]pyridazin-3...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of GSK3beta by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GZNPubMed