null

SMILES CCC(=O)C(CC(C)N(C)C)(c1ccccc1)c1ccccc1

InChI Key InChIKey=USSIQXCVUWKGNF-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 44 hits for monomerid = 82507   

TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMedDrugBank
TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  0.720nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z42X1PubMedDrugBank
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  0.945nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetMu-type opioid receptor(GUINEA PIG)
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.45nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NN9PubMedDrugBank
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  5.60nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TM78M9PubMedDrugBank
TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in HEK293 cell membrane incubated for 60 mins by radioligand binding assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N301V5PubMedDrugBank
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  14.1nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  15.8nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NN9PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TM78M9PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  19.7nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetAldehyde oxidase 1(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of rat aldehyde oxidaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2057G6GPubMed
TargetDelta-type opioid receptor(GUINEA PIG)
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  37.3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  132nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMedDrugBank
TargetKappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  324nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  371nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  405nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  435nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetNorepinephrine transporter(RAT)
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  702nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetKappa-type opioid receptor(Cavia porcellus (domestic guinea pig))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  728nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23J3BH2PubMed
TargetDelta-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  960nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  992nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z42X1PubMedDrugBank
TargetDelta-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CF9NN9PubMedDrugBank
TargetKappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z42X1PubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.37E+3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.86E+3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetD(3) dopamine receptor(Homo sapiens)TBA
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  2.11E+3nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D3 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N301V5PubMed
TargetD(2) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  2.70E+3nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WH6PubMed
TargetD(1A) dopamine receptor(BOVINE)
TBA

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22B8WH6PubMed
TargetCytochrome P450 2B6(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+4nMAssay Description:Inactivation of C-terminal His4-tagged human CYP2B6 lacking 21 N-terminal residues expressed in Escherichia coli C41 (DE3) assessed as decreases in f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21V5GP6PubMedDrugBank
TargetNorepinephrine transporter(RAT)
R.W. Johnson Pharmaceutical Research Institute

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R20ZVXPubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))TBA
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi:  2.62E+4nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D4 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N301V5PubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))TBA
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+5nMAssay Description:Displacement of [3H]-N-methylspiperone from human dopamine D2 receptor expressed in HEK293 cell membranes incubated for 60 mins by microbeta scintill...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N301V5PubMed
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 3.74E+4nMAssay Description:Inhibition of Cav1.2 current measured using QPatch automatic path clamp system in CHO cells expressing Cav1.2, beta-2 and alpha-2/delta-1 subunitsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB77K2PubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HDVPubMed
TargetDelta-type/Kappa-type/Mu-type opioid receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Displacement of [3H]naloxone from Sprague-Dawley rat cerebellum opioid receptor assessed as relative receptor affinity by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1HDVPubMed
TargetMas-related G-protein coupled receptor member X2(Homo sapiens (Human))
University of North Carolina

LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataEC50:  4.40E+4nMpH: 7.4 T: 2°CAssay Description:HTLA cells (HEK-T cells stably expressing a β-arrestin2-TEV fusion protein and a tTa-dependent luciferase reporter) were maintained in DMEM (Cor...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20R9N82PubMed
TargetATP-dependent translocase ABCB1(Homo sapiens (Human))
Tufts University School of Medicine

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+3nMAssay Description:TP_TRANSPORTER: inhibition of Rhodamine 123 transepithelial transport (basal to apical) (Rhodamine 123: 5 uM) in Caco-2 cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2HQ4164PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Binding affinity against mu-opiate receptor (human) using [3H]DAMGO radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMedDrugBank
TargetKappa-type opioid receptor(Homo sapiens (Human))
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 512nMAssay Description:Binding affinity against opioid receptor kappa 1 using [3H]- U-69,593 radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMed
TargetDelta-type opioid receptor(Homo sapiens (Human))
SRI International

Curated by PDSP Ki Database
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.09E+3nMAssay Description:Binding affinity against delta-opiate receptor (human) using [3H]-DPDPE radioligandMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23X87B8PubMedDrugBank
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Reverse proteomics research institute

Curated by ChEMBL
LigandPNGBDBM82507((+/-)-Methadone | CAS_5967-73-7 | METHADONE | Meth...)copy SMILEScopy InChI
Affinity DataIC50: 9.77E+3nMAssay Description:Inhibitory concentration against potassium channel HERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S7CPubMed