null

SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C

InChI Key InChIKey=KALPRSFUZYGTNU-UHFFFAOYSA-N

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 97678   

TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 0.580nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MW2FR5US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CJ8C3GUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 60.9nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Pharmacyclics LLC

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 60.9nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 μM ATP.). For enzyme in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2765D5ZUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:IC50s were determined using the in vitro HotSpot kinase assay (purified enzymes, 33P-ATP, an appropriate substrate and 1 uM ATP.). Reaction condition...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20C4TMXUS Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Pharmacyclics, Inc.

US Patent
LigandPNGBDBM97678(US8476284, 9 | US8497277, 10 | US8497277, 9 | US91...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 7.4Assay Description:Btk kinase activity was determined using a time-resolved fluorescence resonance energy transfer (TR-FRET) methodology. Measurements were performed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WQ02KCUS Patent