Compile Data Set for Download or QSAR
Found 280 Enz. Inhib. hit(s) with Target = 'Serine/threonine-protein kinase SIK2'
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647342(4-(7-(1- cyclopropyl- 1H-pyrazol-4- yl)imidazo[1,2...)copy SMILES
Affinity DataIC50: 0.101nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50601538(CHEMBL5090394)copy SMILES
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66QTGPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.345nMAssay Description:Inhibition of human SIK2 using AMARAASAAALARRR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5KB8PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Inhibition of human SIK2 using AMARAASAAALARRR as substrate by [gamma-33P]-ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W380MTPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647344(US20240025892, Example 51)copy SMILES
Affinity DataIC50: 0.412nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647338(US20240025892, Example 45)copy SMILES
Affinity DataIC50: 0.579nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647340(4-(7-(1-ethyl-1H- pyrazol-4- yl)imidazo[1,2- a]pyr...)copy SMILES
Affinity DataIC50: 0.855nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647298(2-(5-((3-methyloxetan- 3-yl)methoxy)-1H- benzo[d]i...)copy SMILES
Affinity DataIC50: 0.979nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50601534(CHEMBL4539742)copy SMILES
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66QTGPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647310(US20240025892, Example 17)copy SMILES
Affinity DataIC50: 1.04nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647345(US20240025892, Example 52)copy SMILES
Affinity DataIC50: 1.11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647348(US20240025892, Example 55)copy SMILES
Affinity DataIC50: 1.48nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647353(2-cyclopropyl-5- (2,6-dimethoxy- 4-(7-(1-methyl- 1...)copy SMILES
Affinity DataIC50: 1.49nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647346(2-(4-(6-(1- cyclopropyl-1H- pyrazol-4- yl)pyrazolo...)copy SMILES
Affinity DataIC50: 1.77nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647308(US20240025892, Example 15)copy SMILES
Affinity DataIC50: 1.91nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647303(US20240025892, Example 10)copy SMILES
Affinity DataIC50: 2.11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647347(4-(6-(1-cyclopropyl- 1H-pyrazol-4- yl)pyrazolo[1,5...)copy SMILES
Affinity DataIC50: 2.24nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647343(4-(7-(1- (oxetan-3-yl)- 1H-pyrazol-4- yl)imidazo[1...)copy SMILES
Affinity DataIC50: 2.34nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647337(US20240025892, Example 44)copy SMILES
Affinity DataIC50: 2.34nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647354(US20240025892, Example 61)copy SMILES
Affinity DataIC50: 3.07nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647309(US20240025892, Example 16)copy SMILES
Affinity DataIC50: 3.39nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647356(US20240025892, Example 63)copy SMILES
Affinity DataIC50: 3.40nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM192712(HG-9-91-01 (1))copy SMILEScopy InChI
Affinity DataIC50: 3.5nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23777H7PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632979(US20230348453, Compound D7)copy SMILES
Affinity DataIC50: 3.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50152595(CHEMBL3780091)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of SNF1LK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B6203PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647334(US20240025892, Example 41)copy SMILES
Affinity DataIC50: 4.11nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647306(US20240025892, Example 13)copy SMILES
Affinity DataIC50: 4.19nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50148921(CHEMBL3770443)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W66QTGPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647305(US20240025892, Example 12)copy SMILES
Affinity DataIC50: 4.90nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647315(N-((1H- benzo[d]imidazol-2- yl)methyl)-3-(4- cyano...)copy SMILES
Affinity DataIC50: 5.58nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647299(2-(5-((3-methyloxetan- 3-yl)methoxy)-1H- benzo[d]i...)copy SMILES
Affinity DataIC50: 5.75nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50055496(CHEMBL3326006)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of N-terminal GST-tagged full length human QIK (1 to 926 end residues) expressed in baculovirus expression system using fluorecence-labele...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K076ZKPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50055496(CHEMBL3326006)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Inhibition of QIK (unknown origin) by Off-chip Mobility Shift AssayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K075XQPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647336(US20240025892, Example 43)copy SMILES
Affinity DataIC50: 5.89nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 8.0Assay Description:IC50‘s for HG-9-91-01 derivatives were measured by Caliper-based mobility shift assay (PerkinElmer). For these experiments, full length His6-MBP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23777H7PubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM192714(US11725011, Compound YKL-05-95 | YKL-05-095 (3))copy SMILEScopy InChI
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9P2Q
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647328(US20240025892, Example 35)copy SMILES
Affinity DataIC50: 7.55nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647341(US20240025892, Example 48)copy SMILES
Affinity DataIC50: 7.65nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647300(1-(2-(5-((3- methyloxetan-3- yl)methoxy)-1H- benzo...)copy SMILES
Affinity DataIC50: 8.35nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647350(2-ethyl-5-(2- methoxy-4-(7- (1-methyl-1H- pyrazol-...)copy SMILES
Affinity DataIC50: 8.76nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647357(US20240025892, Example 64)copy SMILES
Affinity DataIC50: 8.80nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM50148921(CHEMBL3770443)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human SIK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP554VPubMed
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647318(N-((3H-imidazo[4,5- c]pyridin-2- yl)methyl)-3-(4- ...)copy SMILES
Affinity DataIC50: 9.74nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM647333(2,6-dimethoxy-4-(7-((3- methyloxetan-3- yl)methoxy...)copy SMILES
Affinity DataIC50: 9.87nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632971(N-(2-chloro-4-(fluoromethyl)thiophen- 3-yl)-2-((2-...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632975(N-(2-chloro-4- (difluoromethyl)thiophen-3-yl)-2-((...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632968(N-(2-chloro-4-(fluoromethyl)thiophen- 3-yl)-2-((6-...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632967(N-(4-chloro-2-fluorothiophen-3-yl)-2- ((6-(4-(2-hy...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetSerine/threonine-protein kinase SIK2(Homo sapiens (Human))TBA
LigandPNGBDBM632973(N-(2-chloro-4-(fluoromethyl)thiophen- 3-yl)-2-((2-...)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
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