Compile Data Set for Download or QSAR
Found 36 with Last Name = 'czarna' and Initial = 'a'
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368984(CHEMBL4164814)copy SMILEScopy InChI
Affinity DataKi:  104nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50391956(CHEMBL2152265)copy SMILEScopy InChI
Affinity DataKi:  158nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50341228(1-(4-fluoro-2-(trifluoromethyl)phenyl)-9-(1H-pyraz...)copy SMILEScopy InChI
Affinity DataKi:  252nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368980(CHEMBL4171089)copy SMILEScopy InChI
Affinity DataKi:  383nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368981(CHEMBL4168671)copy SMILEScopy InChI
Affinity DataKi:  575nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1N40PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368986(CHEMBL4171209)copy SMILEScopy InChI
Affinity DataKi:  1.68E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM209414(US9266890, I-24)copy SMILEScopy InChI
Affinity DataKi:  2.02E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368985(CHEMBL4167484)copy SMILEScopy InChI
Affinity DataKi: >2.80E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM7533((2R)-2-[[6-(benzylamino)-9-isopropyl-purin-2-yl]am...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)copy SMILEScopy InChI
Affinity DataIC50: 150nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataIC50: 190nMMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368984(CHEMBL4164814)copy SMILEScopy InChI
Affinity DataIC50: 216nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)copy SMILEScopy InChI
Affinity DataIC50: 270nMMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50391956(CHEMBL2152265)copy SMILEScopy InChI
Affinity DataIC50: 329nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50341228(1-(4-fluoro-2-(trifluoromethyl)phenyl)-9-(1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 532nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368980(CHEMBL4171089)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368981(CHEMBL4168671)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1N40PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368986(CHEMBL4171209)copy SMILEScopy InChI
Affinity DataIC50: 3.50E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM209414(US9266890, I-24)copy SMILEScopy InChI
Affinity DataIC50: 4.20E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50368985(CHEMBL4167484)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) using DYRKtide as substrate by ATP regenerative NADH consuming assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)copy SMILEScopy InChI
Affinity DataIC50: 6.50E+4nMAssay Description:Inhibition of p60 c-SrcMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataKd:  4.80E+3nMMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)copy SMILEScopy InChI
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataKd:  0.380nMMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataKd:  35nMMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM7497(1-Azakenpaullone | 14-bromo-3,8,18-triazatetracycl...)copy SMILEScopy InChI
Affinity DataKd:  35nMMore data for this Ligand-Target Pair
In DepthDetails
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataKd:  38nMMore data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))TBA
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)copy SMILEScopy InChI
Affinity DataKd:  3.56E+3nMMore data for this Ligand-Target Pair
In DepthDetails
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM100152(7-methoxy-1-methyl-9H-beta-carboline;hydrochloride...)copy SMILEScopy InChI
Affinity DataKd:  13nMMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
UiT The Arctic University of Norway

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataKd:  1.80nMMore data for this Ligand-Target Pair
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)copy SMILEScopy InChI
Affinity DataKd:  2.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50272597((trans-2-(4-chlorobenzyl)-3-(4-chlorophenyl)-1-oxo...)copy SMILEScopy InChI
Affinity DataKd:  8.00E+3nMAssay Description:Binding affinity to human wild type Mdm2 by NMR ligand-protein binary titrationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50042949((E)-1-(2,4-dihydroxyphenyl)-3-(3,4-dihydroxyphenyl...)copy SMILEScopy InChI
Affinity DataKd:  1.00E+5nMAssay Description:Binding affinity to CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CZ3821PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Institute for Biochemistry

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataKd:  700nMAssay Description:Binding affinity to human wild type Mdm2 by isothermal titration calorimetryMore data for this Ligand-Target Pair