Affinity DataIC50: 8nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 8.90nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaantibodypediaGoogleScholar
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28P649ZPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28P649ZPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant HDAC6 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of CDK9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q28P649ZPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q28P649ZPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Universit£ Paris-Saclay
Curated by ChEMBL
Universit£ Paris-Saclay
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of DYRK1A (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of human CDK9/cyclin T in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of human GSK3alpha by ADP-Glo assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK1(Homo sapiens (Human))
Universit£ Paris-Saclay
Curated by ChEMBL
Universit£ Paris-Saclay
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of CLK1 (unknown origin)More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 117nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 121nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
Affinity DataIC50: 162nMAssay Description:Inhibition of human CDK2/cyclin A in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 195nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 210nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 216nMAssay Description:Inhibition of human GSK3beta in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 240nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 272nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 284nMAssay Description:Inhibition of human CDK5/p25 in presence of ATP by ADP-glo luminescent assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 310nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of COX2 in human blood assessed as TxB2 level after 1 hr by enzyme immunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Tehran University of Medical Sciences
Curated by ChEMBL
Tehran University of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 340nMAssay Description:Inhibition of COX1 in human blood assessed as PGE2 level incubated for 15 mins prior to LPS-challenge measured after 24 hrs by enzyme immunoassayMore data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of human recombinant HDAC8 after 30 mins using fluorogenic substrate by fluorimetric assayMore data for this Ligand-Target Pair
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