Compile Data Set for Download or QSAR
Found 742 with Last Name = 'heim-riether' and Initial = 'a'
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401764(CHEMBL2207564)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401763(CHEMBL2207565)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126726(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126725(US8785489, 4-{[({5-methyl-4-[2-(3-methyl-1,2,4-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126724(US8785489, 4-{[({5-methyl-4-[2-(3-methyl-1,2,4-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126723(US8785489, 4-{[({4-[2-(3-methyl-1,2,4-oxadiazol-5-...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126722(US8785489, 4-{[({1-methyl-5-[2-(3-methyl-1,2,4-oxa...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401766(CHEMBL2207562)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198921(CHEMBL3889627)copy SMILEScopy InChI
Affinity DataIC50: 0.398nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of CCL27-dependent calcium flux in p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20WFPubMed
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126728(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126727(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM19502((2R)-N-(1-cyanocyclopropyl)-3-(cyclopropylmethane)...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401814(CHEMBL2207591)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401765(CHEMBL2207563)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126730(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126729(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401834(CHEMBL2207571)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401835(CHEMBL2207570)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126731(US8785489, N-(isoxazol-5-ylmethyl)-5-methyl-4-[2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401761(CHEMBL2207567)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50311570(2-(6-(4-(4-aminopyrimidin-2-yloxy)piperidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM58K9PubMed
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126732(US8785489, 4-{[({4-[2-(ethoxycarbonyl)-1H-indol-5-...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126734(US8785489, 4-[({[1-methyl-5-(2-pyrimidin-4-yl-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126733(US8785489, 4-[({[1-methyl-5-(2-pyridin-4-yl-1H-ind...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126736(US8785489, 5-methyl-4-[2-(3-methyl-1,2,4-oxadiazol...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126735(US8785489, 5-methyl-N-[(5-methylisoxazol-3-yl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401770(CHEMBL1236882)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of cathepsin S-mediated antigen presentation in B/T hybridoma cells assessed as IL-2 levelMore data for this Ligand-Target Pair
TargetCollagenase 3(Mus musculus (Mouse))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM126737(US8785489, N-[(2-cyanopyridin-4-yl)methyl]-5-methy...)copy SMILEScopy InChI
Affinity DataIC50: 0.950nMAssay Description:The EnzoLyte 520 Generic MMP Assay Kit (AnaSpec Inc.) can detect the activity of several MMPs including MMP-1, 2, 3, 7, 8, 9, 13, and 14. This kit us...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24B300FUS Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118757(US8674113, 14)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118851(US8674113, 108)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401762(CHEMBL2207566)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118850(US8674113, 107)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118846(US8674113, 103)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118842(US8674113, 99)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118819(US8674113, 76)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118818(US8674113, 75)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118814(US8674113, 71)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198921(CHEMBL3889627)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in mouse BA/F3 cells assessed as inhibition of human CCL27-dependent chemotaxisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20WFPubMed
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198921(CHEMBL3889627)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL27-dependent calcium flu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20WFPubMed
TargetC-C chemokine receptor type 10(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198921(CHEMBL3889627)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human CCR10 expressed in CHOK1 cells coexpressing aequorin/Galphaq assessed as inhibition of human CCL28-dependent calcium flu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KD20WFPubMed
TargetCollagenase 3(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc

Curated by ChEMBL
LigandPNGBDBM50361618(CHEMBL1939876 | US8785489, 4-{[({5-[2-(ethoxycarbo...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human MMP13 expressed in Escherichia coli after 30 mins by fluorimetryMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118803(US8674113, 60 | US8674113, 61)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetCathepsin S(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50401818(CHEMBL2207587)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of cathepsin S using FR-aminoluciferin as substrate preincubated for 15 mins before substrate addition measured after 1 hr by luminescence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R212JHPubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50311564(2-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM58K9PubMed
TargetDeoxycytidine kinase(Homo sapiens (Human))
Princ

Curated by ChEMBL
LigandPNGBDBM50311568(3-(6-(4-(4-amino-5-fluoropyrimidin-2-yloxy)piperid...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human dCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM58K9PubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118800(US8674113, 57)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118799(US8674113, 56)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118782(US8674113, 39)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
TargetProstaglandin E synthase(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM118808(US8674113, 65)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.4 T: 2°CAssay Description:The aim of this assay is to determine the affinity of a test compound for the mPGES-1 enzyme. 47 μl of recombinant human mPGES-1 (0.5 μg p...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2708035US Patent
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