Compile Data Set for Download or QSAR
Found 109 with Last Name = 'lahm' and Initial = 'a'
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of flag-tagged HDAC3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of flag-tagged HDAC4More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Binding affinity to human ER alphaMore data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50238632((6S,9S,12S,14aR)-6-((S)-sec-Butyl)-9-(1-methoxy-1H...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of flag-tagged HDAC3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of HDAC4 catalytic domain expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of flag-tagged HDAC4 expressed in HEK293 cells by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19428((2E)-N-hydroxy-3-(4-{[(2-hydroxyethyl)[2-(1H-indol...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)copy SMILEScopy InChI
Affinity DataIC50: 9.70nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25152(CHEMBL112446 | N-methyl-2-oxo-N'-(3-phenylphenyl)n...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194081(9a-benzyl-7-hydroxy-4-methyl-1,2,9,9a-tetrahydro-3...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 15nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 18nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194087(1-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194080(9a-(4-chlorobenzyl)-7-hydroxy-4-methyl-1,2,9,9a-te...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194091(4-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194088(9a-benzyl-4-butyl-7-hydroxy-1,2,9,9a-tetrahydro-3H...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194075(9a-(4-chlorobenzyl)-7-hydroxy-4-[4-(2-piperidin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 30nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)copy SMILEScopy InChI
Affinity DataIC50: 33nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194076(2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrahydr...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 43nMT: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMedDrugBank
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM25150((2E)-N-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2...)copy SMILEScopy InChI
Affinity DataIC50: 46nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)copy SMILEScopy InChI
Affinity DataIC50: 46nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 57nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMedDrugBank
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194077(9a-(4-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroi...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50377931(CHEMBL1791402)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Inhibition of flag-tagged HDAC4 by Biomol assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194084(9a-benzyl-7-hydroxy-4-(4-hydroxyphenyl)-1,2,9,9a-t...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM19410(CHEMBL27759 | MS-275 | US11377423, MS-275 | US1167...)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM24624(CHEMBL272980 | MGCD-0103 | MGCD0103 | N-(2-aminoph...)copy SMILEScopy InChI
Affinity DataIC50: 130nMpH: 8.0 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194082(9a-benzyl-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194085(9a-(2-fluorobenzyl)-6-methyl-8,9,9a,10-tetrahydroi...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Istituto di Ricerche di Biologia Molecolare

Curated by ChEMBL
LigandPNGBDBM50377931(CHEMBL1791402)copy SMILEScopy InChI
Affinity DataIC50: 152nMAssay Description:Inhibition of flag-tagged HDAC4 by pull-down assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C82B5XPubMed
TargetEstrogen receptor(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194089(9a-benzyl-6-methyl-8,9,9a,10-tetrahydroindeno[2,1-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Binding affinity to ERalpha L384M/M421G mutantMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50194087(1-{2-[4-(9a-benzyl-7-hydroxy-3-oxo-2,3,9,9a-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Binding affinity to human ER betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB81GHPubMed
TargetHistone deacetylase 4 [653-1084,H976Y](Homo sapiens (Human))
IRBM/Merck

LigandPNGBDBM25151(9,9,9-trifluoro-8-oxo-N-(3-phenylphenyl)nonanamide...)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 7.5 T: 2°CAssay Description:The Fluor-de-Lys HDAC activity assay kit (Biomol) was used. Purified recombinant HDAC enzyme was incubated with Fluor-de-Lys substrate in the presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RJ4GSKPubMed
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