Compile Data Set for Download or QSAR
Found 727 with Last Name = 'littlewood-evans' and Initial = 'a'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575488(CHEMBL4852381)copy SMILES
Affinity DataIC50: 0.120nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514642(CHEMBL4593663)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259415(US10457647, Example 14 | US11180460, Example 14 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50076190(CHEMBL3416023)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44S0CPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50076187(CHEMBL3416027 | US9290481, 1.4)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of Syk (unknown origin) using 5-Fluo-Ahx-GAPDYENLQELNKK-Amide as substrate after 60 mins by microfluidic mobility shift assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44S0CPubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50260351(CHEMBL4086667)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0XB3PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM9503(2-[(pyridin-4-ylmethyl)amino]-N-[3-(trifluoromethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259423(US10457647, Example 22 | US11180460, Example 22 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259409(US10457647, Example 8 | US11180460, Example 8 | US...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514634(CHEMBL4450082)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575492(CHEMBL4784496)copy SMILES
Affinity DataIC50: 1.90nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514645(CHEMBL4546324)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514637(CHEMBL4463185)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259407(US10457647, Example 6 | US11180460, Example 6 | US...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of BTK in vitamin D3 differentiated human THP1 cells assessed as inhibition of FCgammaR-induced IL8 production measured after 24 hrs by HT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetCathepsin K(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50260350(CHEMBL4078089)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NS0XB3PubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))TBA
LigandPNGBDBM31085(1-[4-[(4-ethyl-1-piperazinyl)methyl]-3-(trifluorom...)copy SMILEScopy InChI
In DepthDetails
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis Institutes for BioMedical Research

Curated by ChEMBL
LigandPNGBDBM50348515(CHEMBL1233942)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of MK2 mediated anisomycin-stimulated hsp27 phosphorylation in human THP-1 cells by fluorometric analysisChecked by AuthorMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575488(CHEMBL4852381)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575487(CHEMBL4871560)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575486(CHEMBL4857223)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575485(CHEMBL4846099)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575483(CHEMBL4869350)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575482(CHEMBL4870263)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575481(CHEMBL4866709)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575477(CHEMBL4859847)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575478(CHEMBL4858542)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575479(CHEMBL4878813)copy SMILES
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259434(US10457647, Example 33 | US11180460, Example 33 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575484(CHEMBL4847272)copy SMILES
Affinity DataIC50: 3.10nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575489(CHEMBL4871711)copy SMILES
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259422(US10457647, Example 21 | US11180460, Example 21 | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575465(CHEMBL4851581)copy SMILES
Affinity DataIC50: 3.60nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514644(CHEMBL4463650)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM259406(US10457647, Example 5 | US11180460, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575488(CHEMBL4852381)copy SMILES
Affinity DataIC50: 3.70nMAssay Description:Inhibition of LTA4H in human PBMC assessed as reduction of calcium ionophore A23187-stimulated LTB4 generation preincubated for 4 hrs followed by ion...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50514635(CHEMBL4559123)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of full-length human recombinant BTK using FITC-Ahx-TSELKKVVALYDYMPMNAND-NH2 as substrate measured after 60 mins by caliper assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB27FWPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))TBA
LigandPNGBDBM50575468(CHEMBL4879150)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length N-terminal His6-tagged LTA4H (unknown origin) expressed in Escherichia coli BL21 DE3 cells at enzyme concentrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85CZGPubMed
Displayed 1 to 50 (of 727 total ) | Next | Last >>
Jump to: