TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataKi: 3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Affinity DataIC50: 0.300nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Johannes Gutenberg-University
Curated by ChEMBL
Johannes Gutenberg-University
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated human bloodMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 30nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 64nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataIC50: 67nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 72nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 84nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 86nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 113nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 125nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 143nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre
Curated by ChEMBL
Experimental Drug Development Centre
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 187nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 189nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 193nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 217nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 220nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 224nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 229nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Agency for Science, Technology and Research (A*STAR)
Curated by ChEMBL
Affinity DataIC50: 238nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
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