Compile Data Set for Download or QSAR
Found 173 with Last Name = 'matter' and Initial = 'a'
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)copy SMILEScopy InChI
Affinity DataKi:  440nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502433(CHEMBL4575866)copy SMILEScopy InChI
Affinity DataKi:  3.06E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502434(CHEMBL4551647)copy SMILEScopy InChI
Affinity DataKi:  3.90E+3nMAssay Description:Irreversible inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 5 mins followed by substrate addition and measured...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247597(4,5-Bis(4-methoxyphenyl)-3H-1,2-dithiol-3-one | CH...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247826(4,5-bis(4-methoxyphenyl)isothiazole | CHEMBL473946)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247901(4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiole-3-thi...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247827(5-(4-methoxyphenyl)-4-p-tolylisothiazole | CHEMBL5...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM13066(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetic acid...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated human bloodMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375523(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502427(CHEMBL4542517)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375525(4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247578(4-(4-Chlorophenyl)-5-p-tolyl-3H-1,2-dithiol-3-one ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375513((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247851(4-(4-Chlorophenyl)-5-(4-methoxyphenyl)isothiazole ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375522(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375513((4-(3-(4-chlorophenyl)imidazo[1,2-b]pyridazin-6-yl...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375525(4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247902(4,5-bis(4-methoxyphenyl)-3H-1,2-dithiole-3-thione ...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247847(5-(4-Chlorophenyl)-4-p-tolylisothiazole | CHEMBL52...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375522(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455538(CHEMBL4214092)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502413(CHEMBL4521324)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247850(5-(4-Chlorophenyl)-4-(4-methoxyphenyl)isothiazole ...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375543(4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375543(4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375544(4-(6-(4-(morpholine-4-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247849(4,5-Bis(4-chlorophenyl)isothiazole | CHEMBL491088)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 113nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375315((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502429(CHEMBL4475972)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375313((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375353(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455541(CHEMBL4208890)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetHistone-lysine N-methyltransferase SMYD3(Homo sapiens (Human))
Experimental Drug Development Centre

Curated by ChEMBL
LigandPNGBDBM50502416(CHEMBL4472455)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of SMYD3 (unknown origin) using MAP3K2 peptide as substrate pretreated for 30 mins followed by substrate addition and measured after 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B63DWPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455545(CHEMBL4204506)copy SMILEScopy InChI
Affinity DataIC50: 187nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375313((4-(3-(4-hydroxyphenyl)imidazo[1,2-a]pyrazin-6-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 189nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455540(CHEMBL4212480)copy SMILEScopy InChI
Affinity DataIC50: 193nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50038649(2-(6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-di...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247577(5-(4-Chlorophenyl)-4-p-tolyl-3H-1,2-dithiol-3-one ...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetProstaglandin G/H synthase 1(Bos taurus)
Johannes Gutenberg-University

Curated by ChEMBL
LigandPNGBDBM50247848(4-(4-Chlorophenyl)-5-p-tolylisothiazole | CHEMBL49...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of COX1 in bovine platelets assessed as formation of 12-hydroxyheptadecatrienoic acid by HPLCMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X92B4SPubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455543(CHEMBL4211757)copy SMILEScopy InChI
Affinity DataIC50: 217nMAssay Description:Inhibition of GST-tagged MNK2 (72 to 385 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375525(4-(6-(4-(piperazine-1-carbonyl)phenyl)imidazo[1,2-...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM50455541(CHEMBL4208890)copy SMILEScopy InChI
Affinity DataIC50: 224nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1/2(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375543(4-(6-(4-(4-Methylpiperazine-1-carbonyl)phenyl)imid...)copy SMILEScopy InChI
Affinity DataIC50: 229nMAssay Description:Inhibition of MNK1/2 in human HeLa cells assessed as decrease in eIF4E phosphorylation at Ser209 after 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Agency for Science, Technology and Research (A*STAR)

Curated by ChEMBL
LigandPNGBDBM375353(4-(6-(4-(4-(dimethylamino)piperidine-1-carbonyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 238nMAssay Description:Inhibition of GST-tagged MNK1 (37 to 341 residues) (unknown origin) expressed in Escherichia coli BL21(DE3) using JH3 peptide as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20004P7PubMed
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