Compile Data Set for Download or QSAR
Found 182 with Last Name = 'mcloughlin' and Initial = 'a'
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520819(CHEMBL4440913)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101929(3-oxo-18-oxa-2,5,9,11-tetraazahexacyclo[17.6.2.22,...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219021(CHEMBL1203459)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219020(CHEMBL421786)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219019(CHEMBL422323)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109710((S)-4-(2-Dimethylamino-quinoline-7-sulfonyl)-1-[(2...)copy SMILEScopy InChI
Affinity DataIC50: 0.220nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101925(16-benzyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)copy SMILEScopy InChI
Affinity DataIC50: 0.470nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109714((S)-4-Benzofuran-2-ylmethyl-1-[(2S,4R)-2-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109714((S)-4-Benzofuran-2-ylmethyl-1-[(2S,4R)-2-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520815(CHEMBL4574711)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109706((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219020(CHEMBL421786)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Tested in vitro for the ability to inhibit cleavage of a substrate by the wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219019(CHEMBL422323)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109706((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50219021(CHEMBL1203459)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520818(CHEMBL4462922)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520822(CHEMBL4436717)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109705((S)-4-(5-Fluoro-benzofuran-2-ylmethyl)-1-[(2S,4R)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.940nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520818(CHEMBL4462922)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520818(CHEMBL4462922)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520824(CHEMBL4536276)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation pretreated for ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090147((S)-4-(3,4-Dichloro-benzyl)-1-[(2S,4R)-2-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2542MTHPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109708((S)-4-Benzooxazol-2-ylmethyl-1-[(2S,4R)-2-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109709((S)-4-Benzo[d]isoxazol-3-ylmethyl-1-[(2S,4R)-2-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101923(16-ethyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazapen...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109708((S)-4-Benzooxazol-2-ylmethyl-1-[(2S,4R)-2-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101911(16-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-tetraazape...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520815(CHEMBL4574711)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090146((S)-1-[(2S,4R)-2-Hydroxy-4-((1S,2R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory concentration of the compound to prevent cleavage of a substrate by the protease enzymeMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2542MTHPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520816(CHEBI:6498 | LIPOXIN A4)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520816(CHEBI:6498 | LIPOXIN A4)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101916(17-oxo-16-(3-pyridylmethyl)-(16R)-2-oxa-9,11,15,18...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109712((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity of the compound against wild type HIV-1 proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109712((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101918(17-oxo-16-(2-thienylmethyl)-(16R)-2-oxa-9,11,15,18...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520819(CHEMBL4440913)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109698((S)-1-[(2S,4R)-2-Hydroxy-4-((R)-(R)-2-hydroxy-inda...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50109710((S)-4-(2-Dimethylamino-quinoline-7-sulfonyl)-1-[(2...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibitory activity of the compound against mutant HIV-1 (A-44)proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2348JPJPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101917(20-oxo-2-oxa-9,11,15,19-tetraazapentacyclo[19.6.2....)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520823(CHEMBL4434857)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101910(15,20-dioxo-2-oxa-9,11,16,19-tetraazapentacyclo[19...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520819(CHEMBL4440913)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101924(15-benzyl-17-oxo-2-oxa-9,11,15,18-tetraazapentacyc...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101922(16-benzyl-15-methyl-17-oxo-(16R)-2-oxa-9,11,15,18-...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520823(CHEMBL4434857)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50101915(17-methyl-15,18-dioxo-(17R)-2-oxa-9,11,16,19-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:In vitro inhibitory activity to reduce the human farnesyltransferase catalyzed incorporation of [3H]-FPP into recombinant Ras-CVIMMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R210PGPubMed
TargetN-formyl peptide receptor 2(Homo sapiens (Human))
University College Dublin

Curated by ChEMBL
LigandPNGBDBM50520819(CHEMBL4440913)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Agonist activity at ALX/FPR2 in human THP1 cells harboring NF-kB-Luc assessed as inhibition of LPS-induced NFkB signalling activation by measuring re...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PS9PubMed
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