Compile Data Set for Download or QSAR
Found 147 with Last Name = 'murtaza' and Initial = 'a'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Inhibition of TGFBR1 in human whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Mus musculus)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of TGFBR1 in mouse whole blood assessed as apparent inhibition constant by measuring reduction in TGFbeta-induced SMAD phosphorylationMore data for this Ligand-Target Pair
LigandPNGBDBM50552696(CHEMBL4778959)copy SMILES
Affinity DataIC50: 0.220nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552697(CHEMBL4780798)copy SMILES
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552697(CHEMBL4780798)copy SMILES
Affinity DataIC50: 0.460nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509622(CHEMBL4455462)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509619(CHEMBL4440988)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509621(CHEMBL4458215)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50552695(CHEMBL4789200)copy SMILES
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552691(CHEMBL4750822)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552692(CHEMBL4759406)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552696(CHEMBL4778959)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552690(CHEMBL4758114)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
LigandPNGBDBM50552698(CHEMBL4779496)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552702(CHEMBL4748154)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
LigandPNGBDBM50552693(CHEMBL4784181)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552699(CHEMBL4784784)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552689(CHEMBL4790192)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552681(CHEMBL4761884)copy SMILES
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282805(6-(4-(4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidaz...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
LigandPNGBDBM50552688(CHEMBL4748045)copy SMILES
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552684(CHEMBL4749598)copy SMILES
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552700(CHEMBL4741772)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552682(CHEMBL4745378)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552686(CHEMBL4776227)copy SMILES
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552701(CHEMBL4758887)copy SMILES
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509620(CHEMBL4534989)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of His-tagged TGFBR1 kinase domain T204D mutant (unknown origin) incubated for 1 hr by HTRF analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
LigandPNGBDBM50552697(CHEMBL4780798)copy SMILES
Affinity DataIC50: 19nMAssay Description:Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM209597(US9546153, ex. 145 | US9546153, ex. 146)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552680(CHEMBL4793633)copy SMILES
Affinity DataIC50: 20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552694(CHEMBL4758572)copy SMILES
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552683(CHEMBL4761304)copy SMILES
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552696(CHEMBL4778959)copy SMILES
Affinity DataIC50: 32nMAssay Description:Inhibition of HPK1 in anti-CD3/anti-CD28-stimulated human T-cells assessed as inhibition of SLP76 phosphorylation preincubated for 1 hr followed by a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50552680(CHEMBL4793633)copy SMILES
Affinity DataIC50: 38nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552695(CHEMBL4789200)copy SMILES
Affinity DataIC50: 41nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552691(CHEMBL4750822)copy SMILES
Affinity DataIC50: 43nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552692(CHEMBL4759406)copy SMILES
Affinity DataIC50: 43nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50552698(CHEMBL4779496)copy SMILES
Affinity DataIC50: 44nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552693(CHEMBL4784181)copy SMILES
Affinity DataIC50: 46nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50552681(CHEMBL4761884)copy SMILES
Affinity DataIC50: 47nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Mus musculus)
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282825(6-(4-(3-chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of TGFbetaR1 in TGFbeta-stimulated mouse NIH3T3 cells assessed as reduction in SMAD3 phosphorylationMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))TBA
LigandPNGBDBM50552702(CHEMBL4748154)copy SMILES
Affinity DataIC50: 59nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552690(CHEMBL4758114)copy SMILES
Affinity DataIC50: 68nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552688(CHEMBL4748045)copy SMILES
Affinity DataIC50: 79nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552681(CHEMBL4761884)copy SMILES
Affinity DataIC50: 80nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM282792(6-(1-(2,2-difluoroethyl)-4-(4-fluorophenyl)-1H- im...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP56K3PubMed
LigandPNGBDBM50552698(CHEMBL4779496)copy SMILES
Affinity DataIC50: 85nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50509621(CHEMBL4458215)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of TGFBR1 in TGFbeta-stimulated human NHLF cells assessed as reduction in SMAD2 nuclear translocationMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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