Compile Data Set for Download or QSAR
Found 753 with Last Name = 'nikitidis' and Initial = 'a'
TargetGlucocorticoid receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50203422(CHEMBL3937635)copy SMILEScopy InChI
Affinity DataIC50: 0.240nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.248nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.248nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223288((1S,2S)-2-[(5-{(2-Fluoro-2-methylpropyl)[2-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519568(CHEMBL4549822)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.289nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223287((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 0.289nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489245(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489244(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50457410(CHEMBL4213191)copy SMILEScopy InChI
Affinity DataIC50: 0.340nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J5RPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519570(CHEMBL4567083)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519585(CHEMBL4464773)copy SMILEScopy InChI
Affinity DataIC50: 0.381nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489251(2-[(1S)-1-Cyclopropylethyl]-6-(2-{[6-(1,1-dioxido-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489241(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(methylsul...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetGlucocorticoid receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50457406(CHEMBL4208262)copy SMILEScopy InChI
Affinity DataIC50: 0.420nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J5RPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM310035((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)copy SMILEScopy InChI
Affinity DataIC50: 0.483nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223289((1S,2S)-2-({5-[(5-Chloro-2,4-difluorophenyl)(propy...)copy SMILEScopy InChI
Affinity DataIC50: 0.483nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489257(6-(4-Methyl-2-{[6-(2-oxoimidazolidin-1-yl)pyridin-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489256(6-(4-Methyl-2-{[6-(2-oxo-1,3-oxazinan-3-yl)pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489287(6-[2-({6-[(3S)-3-Hydroxy-2-oxopyrrolidin-1-yl]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489281(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489261(2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489283(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3S)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489253(N-{6-[(5-{2-[(1S)-1-Cyclopropylethyl]-7-(ethylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489281(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(3R)-3-hydro...)copy SMILEScopy InChI
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579665(CHEMBL5082066)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579666(CHEMBL5081964)copy SMILES
Affinity DataIC50: 0.501nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50457403(CHEMBL4208798)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J5RPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519591(CHEMBL4562583)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489264(6-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489248(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489237(5-(4-Methyl-2-{[6-(2-oxopyrrolidin-1-yl)pyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519574(CHEMBL4563433)copy SMILEScopy InChI
Affinity DataIC50: 0.626nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM50519588(CHEMBL4584584)copy SMILEScopy InChI
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579667(CHEMBL5090799)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50579668(CHEMBL5091438)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489261(2-[(1S)-1-Cyclopropylethyl]-6-(4-methyl-2-{[6-(2-o...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489248(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
LigandPNGBDBM50579671(CHEMBL5090959)copy SMILES
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kgamma assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM50512861(CHEMBL4558527)copy SMILEScopy InChI
Affinity DataIC50: 0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7ZVJPubMed
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.658nMAssay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester.In order to obtain IC50-va...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2SJ1NPGUS Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.658nMpH: 7.5Assay Description:In the assay, LTC4 synthase catalyses the reaction where the substrate LTA4 methyl ester is converted to LTC4 methyl ester. In order to obtain IC50-v...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2W66JN5US Patent
TargetLeukotriene C4 synthase(Homo sapiens (Human))
Astrazeneca Ab

US Patent
LigandPNGBDBM223290((1S,2S)-2-[(5-{[2-Fluoro-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.660nMAssay Description:Inhibition of human N-terminal His6-tagged LTC4S expressed in Pichia pastoris X33 using LTA4 methyl ester and glutathione as substrate preincubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8XMWPubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM140009(US8901310, Example 1 )copy SMILEScopy InChI
Affinity DataIC50: 0.690nMAssay Description:Transrepression activity at glucocorticoid receptor (unknown origin) expressed in human ChaGoK1 cells assessed as inhibition of PMA-stimulated gene e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XK8J5RPubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489275(2-[(1S)-1-Cyclopropylethyl]-6-(2-{[6-(5,5-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489280(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489284(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[(2S)-2-(hydr...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
AstraZeneca AB

US Patent
LigandPNGBDBM489286(2-[(1S)-1-Cyclopropylethyl]-6-[2-({6-[4-(2-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2M90CS5US Patent
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