Compile Data Set for Download or QSAR
Found 630 with Last Name = 'tabatabaei' and Initial = 'a'
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29100(dibenzothiazepine, 12h)copy SMILEScopy InChI
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29098(dibenzothiazepine, 12e)copy SMILEScopy InChI
Affinity DataKi:  0.200nM ΔG°:  -54.8kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29096(dibenzothiazepine, 12b)copy SMILEScopy InChI
Affinity DataKi:  0.320nM ΔG°:  -53.6kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29097(dibenzothiazepine, 12c)copy SMILEScopy InChI
Affinity DataKi:  0.790nM ΔG°:  -51.4kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29101(dibenzothiazepine, 12j)copy SMILEScopy InChI
Affinity DataKi:  1.20nM ΔG°:  -50.4kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29102(dibenzothiazepine, 12k)copy SMILEScopy InChI
Affinity DataKi:  1.60nM ΔG°:  -49.7kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)copy SMILEScopy InChI
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMedDrugBank
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29095(dibenzothiazepine, 12a)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29094((+/-)-SLV319 | (S)-3-(4-chlorophenyl)-N-(4-chlorop...)copy SMILEScopy InChI
Affinity DataKi:  3nM ΔG°:  -48.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetForkhead box protein M1(Homo sapiens)TBA
LigandPNGBDBM50562257(CHEMBL4740210)copy SMILES
Affinity DataKi:  21nMAssay Description:Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex prein...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V1NPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29099(dibenzothiazepine, 12g)copy SMILEScopy InChI
Affinity DataKi:  25nM ΔG°:  -43.0kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 1(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29103(dibenzothiazepine, 13)copy SMILEScopy InChI
Affinity DataKi:  40nM ΔG°:  -41.8kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetForkhead box protein M1(Homo sapiens)TBA
LigandPNGBDBM50085045(5-((4-((6-hydroxy-2,5,7,8-tetramethyl-3,4-dihydro-...)copy SMILEScopy InChI
Affinity DataKi:  52nMAssay Description:Binding affinity to recombinant FOXM1 DBD (unknown origin) expressed in Escherichia coli BL21 (DE3) assessed as disruption of FOXM1-DNA complex prein...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G44V1NPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM21278(5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl...)copy SMILEScopy InChI
Affinity DataKi:  398nM ΔG°:  -36.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29100(dibenzothiazepine, 12h)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nM ΔG°:  -33.9kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29097(dibenzothiazepine, 12c)copy SMILEScopy InChI
Affinity DataKi:  1.26E+3nM ΔG°:  -33.3kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29094((+/-)-SLV319 | (S)-3-(4-chlorophenyl)-N-(4-chlorop...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nM ΔG°:  -32.2kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
TargetCannabinoid receptor 2(Homo sapiens (Human))
ACADIA Pharmaceuticals AB

LigandPNGBDBM29099(dibenzothiazepine, 12g)copy SMILEScopy InChI
Affinity DataKi:  5.01E+3nM ΔG°:  -29.9kJ/molepH: 7.2 T: 2°CAssay Description:IC50 values for test compounds were determined from nonlinear regression analysis of data collected from ligand displacement experiments. The inhibit...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25Q4TFPPubMed
LigandPNGBDBM50150119(CHEMBL3769414)copy SMILEScopy InChI
Affinity DataIC50: 0.0580nMAssay Description:Inhibition of PDE1B (unknown origin)More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236228(CHEMBL4076035 | US11186582, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236271(CHEMBL4103411 | US11186582, Example 225)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236235(CHEMBL4066029 | US11186582, Example 4)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM107767(US11419874, PF-05180999 | US8598155, 2)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human full length PDE2a using cGMP as substrate by Scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457704(CHEMBL4202565)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236231(CHEMBL4087945 | US11186582, Example 349 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Tested for the inhibitory activity against pepsin (Second pure eluting diastereomer )More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236243(CHEMBL4059930 | US11186582, Example 340)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PDE2a (unknown origin) using cAMP as substrate after 30 mins by Scintillation proximity assayMore data for this Ligand-Target Pair
LigandPNGBDBM289647(11,11-Difluoro-6-(4-methoxybenzyl)-9-((tetrahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory activity against chymotrypsinogen; Range 1-10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D79DP3PubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236242(CHEMBL4093237 | US11186582, Example 516)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457706(CHEMBL4216391)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457693(CHEMBL4218366)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236226(CHEMBL4087412 | US11186582, Example 378 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457694(CHEMBL4211535)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457685(CHEMBL4210484)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457692(CHEMBL4211012)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457689(CHEMBL4206403)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457695(CHEMBL4217712)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457704(CHEMBL4202565)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543922(CHEMBL4640428)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457703(CHEMBL4214250)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50543917(CHEMBL4638182)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of GlyT1 in rat primary cortical neurons assessed as reduction in radiolabeled glycine uptake by scintillation proximity assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29027C0PubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457695(CHEMBL4217712)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236236(CHEMBL4095099 | US11186582, Example 5)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q242GFPubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Dart Neuroscience LLC

Curated by ChEMBL
LigandPNGBDBM50236225(CHEMBL4074744 | US11186582, Example 269 | US114198...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human full length GST-tagged PDE2a using FAM-labeled cAMP as substrate preincubated for 5 mins followed by substrate addition measured ...More data for this Ligand-Target Pair
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457714(CHEMBL4214756)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457692(CHEMBL4211012)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457688(CHEMBL4206639)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(attus norvegicus (Rat))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457691(CHEMBL4209849)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of GlyT1 in primary rat cortical neurons assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation counting meth...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457702(CHEMBL4205995)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
TargetSodium- and chloride-dependent glycine transporter 1(Homo sapiens (Human))
Dart NeuroScience LLC

Curated by ChEMBL
LigandPNGBDBM50457710(CHEMBL4210353)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human GlyT1c expressed in HEK293 cells assessed as reduction in [14C]glycine uptake after 2 hrs by microbeta scintillation ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GB26PMPubMed
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