Compile Data Set for Download or QSAR
Found 38 with Last Name = 'clark' and Initial = 'ad'
TargetReverse transcriptase(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50369390(CHEMBL54224)copy SMILEScopy InChI
Affinity DataIC50: 223nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50369390(CHEMBL54224)copy SMILEScopy InChI
Affinity DataIC50: 223nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50369390(CHEMBL54224)copy SMILEScopy InChI
Affinity DataIC50: 244nMAssay Description:Inhibition of HIV-1 reverse transcriptase K101E mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 400nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50175609(5-{3-[4-Amino-9-(tert-butyl-dimethyl-silanyloxy)-6...)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetGag-Pol polyprotein [600-1028,Y780C]/[600-1151,Y780C](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,L699I,K702N,C879S]/[600-1151,L699I,K702N,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33961(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetGag-Pol polyprotein [600-1028,Y787L]/[600-1151,Y787L](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33958(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33957(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50192289(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)copy SMILEScopy InChI
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33958(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50483735(CHEMBL1766951)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of wild type HIV-1 reverse transcriptase-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33961(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33956(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33955(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33954(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33957(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33955(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33954(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33956(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50192289(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)copy SMILEScopy InChI
Affinity DataIC50: 1.65E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50192289(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)copy SMILEScopy InChI
Affinity DataIC50: 1.65E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase K101E mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
Rutgers University

Curated by ChEMBL
LigandPNGBDBM50169035(1-[(5R,6R,8R,9R)-4-amino-9-(tert-butyl-dimethyl-si...)copy SMILEScopy InChI
Affinity DataIC50: 1.69E+5nMAssay Description:Inhibition of HIV-1 reverse transcriptase E138K mutant-mediated polymerization reaction after 30 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5CPWPubMed
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,L699I,K702N,C879S]/[600-1151,L699I,K702N,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y787L]/[600-1151,Y787L](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y780C]/[600-1151,Y780C](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair