In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human TNKS2 (873 to 1162 residues) assessed as reduction in NAD+ consumption by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of TNKS2 (unknown origin) expressed in HEK293 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 24 hrs by luc...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human 6xHis-tagged TNKS1 ART domain (1030 to 1317 residues) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ a...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of CYP1A2 in human liver microsome using phenacetin as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of CYP2D6 in human liver microsome using dextromethorphan as substrateMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Leibniz-Forschungsinstitut f�r Molekulare Pharmakologie (FMP)
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of TNKS2 (unknown origin) transfected in human SW480 cells assessed as inhibition of Wnt3a-induced Wnt/beta-catenin signaling after 48 hrs...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of CYP3A4 in human liver microsome using midazolam as substrateMore data for this Ligand-Target Pair
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