Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
In DepthDetails
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse full length GST-tagged BRAF V600E mutant using recombinant human His6-tagged MEK1 as substrate preincubated for 1 hr followed by ...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Beni-Suef University
Curated by ChEMBL
Beni-Suef University
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of recombinant full-length GST-tagged human B-RAF V600E mutant (417 to 766 residues) expressed in Baculovirus infected Sf9 cells using N-t...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (unknown origin) (645 to 1186 residues) expressed in baculovirus infected Sf-9 cells pr...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2H41TV5PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2H41TV5PubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 70nMAssay Description:Inhibition of His6-tagged recombinant EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in baculovirus infected Sf9 insect ce...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2GF0X69PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2GF0X69PubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of His6-tagged EGFR (unknown origin) cytoplasmic domain expressed in baculovirus infected Sf9 insect cells after 10 mins followed by addit...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q25X2CKDPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q25X2CKDPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Wuhan University of Technology
Curated by ChEMBL
Wuhan University of Technology
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of His-6 tagged recombinant EGFR cytoplasmic domain (645 to 1186 residues) (unknown origin) expressed in Baculovirus infected Sf9 cells by...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q26D5WNSPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q26D5WNSPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
Affinity DataIC50: 100nMAssay Description:Inhibition of mouse full-length GST-tagged BRAF V600E mutant using recombinant human full length N-terminal His-tagged MEK1 as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
In DepthDetails
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 190nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
In DepthDetails
In DepthDetails
Affinity DataIC50: 280nMAssay Description:Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair
Affinity DataIC50: 290nMAssay Description:Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Affinity DataIC50: 320nMAssay Description:Inhibition of ovine COX-1 assessed as reduction in oxidation of TMPD using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 340nMAssay Description:Inhibition of human recombinant COX-2 assessed as reduction in oxidation of TMPD using arachidonic acid as substrate preincubated for 5 mins followed...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of human sEH using epoxy flour 7 as substrate measured after 30 mins by cell-based fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair
Affinity DataIC50: 410nMAssay Description:Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced iNOS activity incubated for 30 mins prior to LPS challenge me...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Ovis aries (Sheep))
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Umm Al-Qura University, Makkah 21955, Saudi Arabia; Department of Medicinal Chemistry, Faculty of Pharmacy, Beni-Suef University, Beni-Sue
Curated by ChEMBL
Affinity DataIC50: 420nMAssay Description:Inhibition of ovine COX-1 assessed as reduction in oxidation of TMPD using arachidonic acid as substrate preincubated for 5 mins followed by substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 450nMAssay Description:Inhibition of human recombinant COX2 assessed as reduction in PGH2 formation by measuring PGF2alpha by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails
![](/img/powered_by_small.gif)