Compile Data Set for Download or QSAR
Found 55 with Last Name = 'prongay' and Initial = 'aj'
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9761(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  10nM ΔG°:  -46.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9763(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -45.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12311((1R,5S)-N-[3-Amino-1-(cyclobutylmethyl)-2,3-dioxop...)copy SMILEScopy InChI
Affinity DataKi:  14nM ΔG°:  -45.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12287(SCH 491762 | tert-butyl N-[(1S)-2-[(1R,2S,5S)-2-[(...)copy SMILEScopy InChI
Affinity DataKi:  15nM ΔG°:  -45.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17886(3-{[(1S,5R)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  19nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9760(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9753(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  19nM ΔG°:  -44.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9758(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  20nM ΔG°:  -44.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9762(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  21nM ΔG°:  -44.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9754(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  27nM ΔG°:  -43.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17898(Ketoamide inhibitor, 35 | N-{1-[(1R,5S)-2-[(1-carb...)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9752(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  40nM ΔG°:  -42.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9756(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  41nM ΔG°:  -42.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17884(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9759(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  51nM ΔG°:  -42.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9757(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  53nM ΔG°:  -42.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17875(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-2-cy...)copy SMILEScopy InChI
Affinity DataKi:  54nM ΔG°:  -42.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM12297(1,1-Dimethylethyl-[1(S)-[[(1R,5S)-2(S)-[[[3-amino-...)copy SMILEScopy InChI
Affinity DataKi:  57nM ΔG°:  -42.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17896(Ketoamide inhibitor, 33 | propan-2-yl N-{2-[(1R,5S...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17897(Ketoamide inhibitor, 34 | N-{2-[(1R,5S)-2-[(1-carb...)copy SMILEScopy InChI
Affinity DataKi:  68nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9751(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  81nM ΔG°:  -41.2kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9755(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  90nM ΔG°:  -40.9kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17893(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3-me...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17882(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  100nM ΔG°:  -40.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9750(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  110nM ΔG°:  -40.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50171301((S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-o...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Ability to inhibit the hydrolysis of chromogenic 4-phenylazophenyl ester from the peptide fragment Ac- DTEDVVP(Nva)-O-4-PAP in a HCV protease continu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17885(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  115nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17887(3-{[(1S,5R)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50171302((S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-o...)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Ability to inhibit the hydrolysis of chromogenic 4-phenylazophenyl ester from the peptide fragment Ac- DTEDVVP(Nva)-O-4-PAP in a HCV protease continu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17876(Ketoamide inhibitor, 5 | tert-butyl N-{1-[(1R,5S)-...)copy SMILEScopy InChI
Affinity DataKi:  220nM ΔG°:  -38.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17895(Ketoamide inhibitor, 32 | ethyl N-{2-[(1R,5S)-2-[(...)copy SMILEScopy InChI
Affinity DataKi:  230nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50171305((S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-o...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Ability to inhibit the hydrolysis of chromogenic 4-phenylazophenyl ester from the peptide fragment Ac- DTEDVVP(Nva)-O-4-PAP in a HCV protease continu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50171302((S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-o...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Ability to inhibit the hydrolysis of chromogenic 4-chlorophenylbutyric acid ester from the peptide fragment Ac- DTEDVVP(Nva)-O-4-PAP in a HCV proteas...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17877(Ketoamide inhibitor, 6 | tert-butyl N-{1-[(1R,5S)-...)copy SMILEScopy InChI
Affinity DataKi:  360nM ΔG°:  -37.4kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17878(Ketoamide inhibitor, 8 | tert-butyl N-{1-[(1R,5S)-...)copy SMILEScopy InChI
Affinity DataKi:  480nM ΔG°:  -36.7kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17888(3-{[(3aR,6aR)-5-{2-[(tert-butylcarbamoyl)amino]-3,...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus)
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50370596(CHEMBL1169404)copy SMILEScopy InChI
Affinity DataKi:  800nMAssay Description:Ability to inhibit the hydrolysis of chromogenic 4-phenylazophenyl ester from the peptide fragment Ac- DTEDVVP(Nva)-O-4-PAP in a HCV protease continu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17894(Ketoamide inhibitor, 31 | methyl N-{2-[(1R,5S)-2-[...)copy SMILEScopy InChI
Affinity DataKi:  800nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17890(3-{[(1R,5R)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  960nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17891(2-{2-[(tert-butylcarbamoyl)amino]-3,3-dimethylbuta...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17874(Ketoamide inhibitor, 36 | SCH 571696 | tert-butyl ...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+3nM ΔG°:  -34.0kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9748(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  1.50E+3nM ΔG°:  -33.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17881(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  1.60E+3nM ΔG°:  -33.6kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17883(3-{[(1R,5S)-3-{2-[(tert-butylcarbamoyl)amino]-3,3-...)copy SMILEScopy InChI
Affinity DataKi:  1.80E+3nM ΔG°:  -33.3kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Schering Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50171301((S)-(2-{3-[((9S,12S)-12-Cyclohexyl-11,14-dioxo-2-o...)copy SMILEScopy InChI
Affinity DataKi:  2.90E+3nMAssay Description:Binding constant towards Human neutrophil elastase HNE proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN45T7PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17879(Ketoamide inhibitor, 9 | tert-butyl N-{1-[(1R,5S)-...)copy SMILEScopy InChI
Affinity DataKi: >3.30E+3nM ΔG°: >-31.8kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9749(2-(3-{[(3S)-2-[(2S)-2-{[(tert-butoxy)carbonyl]amin...)copy SMILEScopy InChI
Affinity DataKi:  3.80E+3nM ΔG°:  -31.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17873((2S)-2-(2-{3-[(2S)-4-methyl-2-[(4E)-7-methyl-2-(pr...)copy SMILEScopy InChI
Affinity DataKi:  4.30E+3nM ΔG°:  -31.1kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM17889(3-[(1-{2-[(tert-butylcarbamoyl)amino]-3,3-dimethyl...)copy SMILEScopy InChI
Affinity DataKi:  5.00E+3nMAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27D2SDKPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Schering-Plough Research Institute

LigandPNGBDBM9747(2-aza-bicyclo[2.2.1]heptane-3-carboxylic acid deri...)copy SMILEScopy InChI
Affinity DataKi:  5.50E+3nM ΔG°:  -30.5kJ/molepH: 6.5 T: 2°CAssay Description:Proteolytic cleavage of the ester linkage between the Nva (L-norvaline) and the chromophore (PAP) was monitored for change in absorbance at 370 nm. I...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B856BBPubMed
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