Compile Data Set for Download or QSAR
Found 186 with Last Name = 'brodie' and Initial = 'am'
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50435992(CHEMBL2392006)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063476((3S,10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075389(CHEMBL3415119)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075391(CHEMBL3415124)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063475((10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-1,2,6,7,...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075392(CHEMBL3415125)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063479((10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075388(CHEMBL3415117)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063480((3S,10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31768(CHEMBL295698 | Ketoconazole | Nizoral | Panfungol)copy SMILEScopy InChI
Affinity DataKi:  38nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063478((10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Binding affinity for Cytochrome P450 17A1 (17-alpha-hydroxypregnenolone Km=560 nM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075390(CHEMBL3415123)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50128548(1-(1-Biphenyl-4-yl-2-phenyl-methyl)-1H-imidazole |...)copy SMILEScopy InChI
Affinity DataKi:  56.5nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31774(CHEMBL104 | Canesten | Clotrimazole | Lotrimin | M...)copy SMILEScopy InChI
Affinity DataKi:  81.5nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31772(1-[2-(2,4-dichlorobenzyl)oxy-2-(2,4-dichlorophenyl...)copy SMILEScopy InChI
Affinity DataKi:  243nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM31773(ECONAZOLE | Econazole nitrate | Gyno-pevaryl | Pev...)copy SMILEScopy InChI
Affinity DataKi:  325nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50370218(TIOCONAZOLE)copy SMILEScopy InChI
Affinity DataKi:  505nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50128554(1-(2,6-Dichloro-phenyl)-2-(2,4-dichloro-phenyl)-3-...)copy SMILEScopy InChI
Affinity DataKi:  610nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of [1-beta-2beta-3H]- -testosterone binding to human steroid 5-alpha-reductase type 2 of BPH tissue at 10 uMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NHVPubMedDrugBank
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063475((10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-1,2,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075391(CHEMBL3415124)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50435992(CHEMBL2392006)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063475((10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-1,2,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of rat Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063479((10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of rat cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of rat Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063476((3S,10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of rat Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50091698((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 10.9nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063478((10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of rat Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063476((3S,10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075389(CHEMBL3415119)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50054203(1-((3S,10R,13S)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human testicular steroid 17-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84B07PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50054203(1-((3S,10R,13S)-3-Hydroxy-10,13-dimethyl-2,3,4,7,8...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human testicular steroid 17-alpha-hydroxylaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84B07PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50075392(CHEMBL3415125)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human CYP17 using 17alpha-hydroxypregnenolone substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063479((10R,13S)-10,13-Dimethyl-17-[1,2,3]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158411((2E,4E,6E,8E)-9-(3-Imidazol-1-yl-2,6,6-trimethyl-c...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cells assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158410(4-((+/-)-(1H-imidazol-1-yl)-N-(imidazolyl)-(E)-ret...)copy SMILEScopy InChI
Affinity DataIC50: 24.7nMAssay Description:Inhibition of ATRA-induced CYP26 in human MCF7 cells assessed ATRA as metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Rattus norvegicus (Rat))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063480((3S,10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of rat cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
TargetCytochrome P450 26A1(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50158415(4-((+/-)-(1H-imidazol-1-yl)-(E)-methylretinoate | ...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of ATRA-induced CYP26 in human T47D cell microsome assessed as ATRA metabolism using [11.12-3H]-ATRAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64HJVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50097370(1-((1H-imidazol-1-yl)methyl)-4-bromo-9H-xanthen-9-...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:In vitro inhibition of human Cytochrome P450 17A1 activityMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50435992(CHEMBL2392006)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human CYP17 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3VFFPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:In vitro cytochrome P450 17A1 inhibition was assayed using the rapid acetic acid releasing assay (AARA), utilizing intact P450c17-expressing Escheric...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WD41B7PubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063477((3S,10R,13S)-17-Imidazol-1-yl-10,13-dimethyl-2,3,4...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:In vitro inhibitory concentration against Cytochrome P450 17 expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TH8NHVPubMed
TargetSteroid 17-alpha-hydroxylase/17,20 lyase(Homo sapiens (Human))
University of Maryland

Curated by ChEMBL
LigandPNGBDBM50063478((10R,13S)-10,13-Dimethyl-17-[1,2,4]triazol-1-yl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of human testicular microsomal Cytochrome P450 17A1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GH9H2NPubMed
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