Compile Data Set for Download or QSAR
Found 803 with Last Name = 'hird' and Initial = 'aw'
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508937(CHEMBL4448046)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203869(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)copy SMILEScopy InChI
Affinity DataKi:  0.900nM ΔG°:  -51.5kJ/mole IC50: 3.40nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203875(7-(3-((4-Borono-3-formylphenoxy)methyl)-1,5-dimeth...)copy SMILEScopy InChI
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50: 4.20nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203870(7-(3-((3-Acetyl-4-boronophenoxy)methyl)-1,5-dimeth...)copy SMILEScopy InChI
Affinity DataKi:  1.20nM ΔG°:  -50.7kJ/mole IC50: 4.70nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203876(Mcl-1 inhibitor 12)copy SMILEScopy InChI
Affinity DataKi:  1.60nM ΔG°:  -50.0kJ/mole IC50: 5.96nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203871(7-(3-((3-formylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataKi:  16nM ΔG°:  -44.3kJ/mole IC50: 59.5nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508939(CHEMBL4443085)copy SMILEScopy InChI
Affinity DataKi:  42nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203873(7-(3-((4-Boronophenoxy)methyl)-1,5-dimethyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataKi:  44nM ΔG°:  -41.8kJ/mole IC50: 162nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508950(CHEMBL4472439)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203872(7-(3-((3-Acetylphenoxy)methyl)-1,5-dimethyl-1H-pyr...)copy SMILEScopy InChI
Affinity DataKi:  64nM ΔG°:  -40.9kJ/mole IC50: 237nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1 [171-327](Homo sapiens (Human))
Oncology Innovative Medicines Unit

LigandPNGBDBM203874(Mcl-1 inhibitor 10)copy SMILEScopy InChI
Affinity DataKi:  104nM ΔG°:  -39.7kJ/mole IC50: 383nMpH: 7.4 T: 2°CAssay Description:TR-FRET assay was used to assess the ability of compounds to disrupt the interaction between recombinant human Mcl-1 and a labeled BIM peptide probe....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1513PubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508947(CHEMBL4460550)copy SMILEScopy InChI
Affinity DataKi:  155nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508938(CHEMBL1984039)copy SMILEScopy InChI
Affinity DataKi:  290nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508940(CHEMBL4582512)copy SMILEScopy InChI
Affinity DataKi:  739nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508942(CHEMBL4449849)copy SMILEScopy InChI
Affinity DataKi:  1.99E+3nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508941(CHEMBL4442625)copy SMILEScopy InChI
Affinity DataKi:  4.96E+3nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508941(CHEMBL4442625)copy SMILEScopy InChI
Affinity DataKi:  4.96E+3nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50508936(CHEMBL4590345)copy SMILEScopy InChI
Affinity DataKi:  5.21E+3nMAssay Description:Inhibition of Mcl1 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6PNHPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50539187(CHEMBL4632769)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50539188(CHEMBL4637222)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoMCE
PC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50249522(2-chloro-N-(4-chloro-3-(pyridin-2-yl)phenyl)-4-(me...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388722(CHEMBL2059865)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of SMO-mediated hedgehog signalling pathway in human HPEM cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CF9TNCPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388706(CHEMBL2059863)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388707(CHEMBL2059864)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed
TargetB-cell lymphoma 6 protein(Homo sapiens)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50239363(CHEMBL4094351)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of Bcl6 (unknown origin) by TR-FRET assayMore data for this Ligand-Target Pair
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM454567(US10717746, Example 48)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90D8VPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588261(CHEMBL5170524)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588290(CHEMBL5191725)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM454570(US10717746, Example 51)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90D8VPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM167534(US9073922, 18 | US9796708, Example 18)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588255(CHEMBL5170195)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588263(CHEMBL5198038)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588264(CHEMBL5207871)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50001129(CHEMBL3236390)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416ZJ7PubMed
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50001129(CHEMBL3236390)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of cIAP1 BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416ZJ7PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588263(CHEMBL5198038)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588272(CHEMBL5180640)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588266(CHEMBL5181709)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM454542(US10717746, Example 25 | US10717746, Example 84)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M90D8VPubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50001129(CHEMBL3236390)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416ZJ7PubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50001129(CHEMBL3236390)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2416ZJ7PubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588273(CHEMBL5192311)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588285(CHEMBL5179773)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50588261(CHEMBL5170524)copy SMILES
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F193PMPubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50387299(CHEMBL2048873)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human PIM3 using FITC-(AHX)RSRHSSYPAGT-COOH as substrate after 90 mins by mobility shift assay in presence of 50 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MDSPubMed
TargetCyclin-T1/Cyclin-dependent kinase 9(Homo sapiens (Human))TBA
LigandPNGBDBM50528817(CHEMBL4462530 | US10717746, Example 14 | US2023041...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant full length human N-terminal GST-fused CDK9 (1 to 372 residues)/His-tagged CyclinT1 (1 to 726 residues) expressed in baculo...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50387299(CHEMBL2048873)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human PIM1 using FITC-(AHX)RSRHSSYPAGT-COOH as substrate after 90 mins by mobility shift assay in presence of 5 mM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348MDSPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50388705(CHEMBL2059859)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Smo expressed in mouse NIH/3T3 cells after 20 hrs by Gli reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W37XCGPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Oncology Chemistry, IMED Biotech Unit, AstraZeneca , 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States.

Curated by ChEMBL
LigandPNGBDBM50389803(AZD7762 | CHEMBL2041933)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of CHK1 (unknown origin)More data for this Ligand-Target Pair
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