Compile Data Set for Download or QSAR
Found 479 with Last Name = 'dave' and Initial = 'b'
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059233(4-(1-Benzyl-piperidin-4-yl)-6-(4-chloro-phenyl)-py...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)copy SMILEScopy InChI
Affinity DataKi:  1nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha5-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)copy SMILEScopy InChI
Affinity DataKi:  1.10nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50050474(4-[5-(4-Chloro-phenyl)-4-methyl-1H-pyrazol-3-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  1.40nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D2 stably expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMedDrugBank
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059230(1-Benzyl-4-[5-(4-chloro-phenyl)-4-ethyl-1H-pyrazol...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059228(1-Benzyl-4-[5-(4-chloro-phenyl)-4-methyl-1H-pyrazo...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(3) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D3 (hD3) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)copy SMILEScopy InChI
Affinity DataKi:  2.30nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50050471(4-[3-(4-Chloro-phenyl)-4-methyl-isoxazol-5-yl]-1-p...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059219(4-(4-Methyl-5-phenyl-1H-pyrazol-3-yl)-1-phenethyl-...)copy SMILEScopy InChI
Affinity DataKi:  3.10nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112233(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  3.40nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50050476(4-[5-(4-Chloro-phenyl)-4-methyl-isoxazol-3-yl]-1-p...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112224(3-(4-Fluoro-phenyl)-1-methyl-5-(4-methyl-thiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50050475(1-(4-Chloro-benzyl)-4-[3-(4-chloro-phenyl)-isoxazo...)copy SMILEScopy InChI
Affinity DataKi:  3.60nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112218(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  3.80nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)copy SMILEScopy InChI
Affinity DataKi:  3.90nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112232(5-(4-Methoxy-phenyl)-1-methyl-3-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  4.10nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059240(4-(4-Chloro-phenyl)-5-methyl-6-(1-phenethyl-piperi...)copy SMILEScopy InChI
Affinity DataKi:  4.70nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112218(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  5nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50050472(4-[5-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-1-phenethy...)copy SMILEScopy InChI
Affinity DataKi:  5.5nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)copy SMILEScopy InChI
Affinity DataKi:  5.70nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM25878(5-(2-fluorophenyl)-1-methyl-7-nitro-2,3-dihydro-1H...)copy SMILEScopy InChI
Affinity DataKi:  5.90nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112220(3-(4-Methoxy-phenyl)-1-methyl-5-thiazol-2-yl-1H-[2...)copy SMILEScopy InChI
Affinity DataKi:  6.20nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  6.60nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112232(5-(4-Methoxy-phenyl)-1-methyl-3-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  6.60nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112237(1'-Methyl-5'-(4-methyl-thiazol-2-yl)-1'H-[4,2';3',...)copy SMILEScopy InChI
Affinity DataKi:  6.70nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089761((R)-1-[2-(1H-Indol-3-yl)-2-oxo-acetyl]-piperidine-...)copy SMILEScopy InChI
Affinity DataKi:  7.30nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112224(3-(4-Fluoro-phenyl)-1-methyl-5-(4-methyl-thiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50065229(4-Ethyl-6,7-dimethoxy-9H-beta-carboline-3-carboxyl...)copy SMILEScopy InChI
Affinity DataKi:  8.30nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(2) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059233(4-(1-Benzyl-piperidin-4-yl)-6-(4-chloro-phenyl)-py...)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D2 stably expressed in CHO cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112233(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Displacement of [3H]-Ro-15-1788 from human Gamma-aminobutyric-acid A receptor alpha2-beta3-gamma2 stably expressed in L(tk-) cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059239(1-Benzyl-4-[5-(4-chloro-phenyl)-1H-pyrazol-3-yl]-p...)copy SMILEScopy InChI
Affinity DataKi:  9.10nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059235(4-(5-Cyclohexyl-1H-pyrazol-3-yl)-1-phenethyl-piper...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMedDrugBank
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059227(1-Benzyl-4-(5-phenyl-1H-pyrazol-3-yl)-piperidine |...)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112219(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-3-yl-1H-[...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50454602(CHEMBL2112285)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50000766(CHEMBL12 | DIAZEPAM | US9271961, Diazepam)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-1-beta-2-gamma-2 expr...More data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112223(5-(4-Cyclopropyl-thiazol-2-yl)-3-(4-methoxy-phenyl...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112218(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  12.8nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetD(4) dopamine receptor(Human)
Merck Sharp and Dohme

Curated by ChEMBL
LigandPNGBDBM50059242(4-[5-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-1-cyclohex...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Ability to displace [3H]-spiperone from human dopamine receptor D4 (hD4) receptor stably expressed in HEK-293 cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PN94R9PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112224(3-(4-Fluoro-phenyl)-1-methyl-5-(4-methyl-thiazol-2...)copy SMILEScopy InChI
Affinity DataKi:  13nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089768(1-[2-(1H-Indol-3-yl)-2-oxo-acetyl]-piperidine-3-ca...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-2/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089762((3S,5R)-1-[2-(1H-Indol-3-yl)-2-oxo-acetyl]-piperid...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Binding affinity evaluated by ability to displace [3H]-Ro-15-1788 from recombinant human Gamma-aminobutyric acid A receptor alpha-2-beta-3-gamma-2 ex...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112231(3-(4-Methoxy-phenyl)-1-methyl-5-thiophen-2-yl-1H-[...)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Binding affinity by displacement of [3H]-Ro-15-1788 from recombinant human gamma-aminobutyric-acid A receptor alpha3,beta3,gamma2 stably expressed in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112233(3-(4-Methoxy-phenyl)-1-methyl-5-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50112232(5-(4-Methoxy-phenyl)-1-methyl-3-(4-methyl-thiazol-...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Inhibition of [3H]-Ro-15-1788 binding to human GABA A receptor (alpha1-beta3-gamma2) stably expressed in L(tk-) cells.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KP81HZPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Human)
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50089770(1-(1,3-Dihydro-isoindol-2-yl)-2-(1H-indol-3-yl)-et...)copy SMILEScopy InChI
Affinity DataKi:  19nMAssay Description:Binding affinity evaluated by ability to displace [3H]Ro-151788 from recombinant human Gamma-aminobutyric acid A receptor alpha-3-beta-3-gamma-2 expr...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KD1X5TPubMed
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