Compile Data Set for Download or QSAR
Found 884 with Last Name = 'kane' and Initial = 'b'
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)copy SMILEScopy InChI
Affinity DataKi:  17.5nMAssay Description:Displacement of [3H]diprenorphine from rat kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0NHBPubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50372492(CHEMBL269849)copy SMILEScopy InChI
Affinity DataKi:  245nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0NHBPubMed
TargetKappa-type opioid receptor(Rattus norvegicus (rat))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50372492(CHEMBL269849)copy SMILEScopy InChI
Affinity DataKi:  1.38E+3nMAssay Description:Displacement of [3H]diprenorphine from rat kappa opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0NHBPubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)copy SMILEScopy InChI
Affinity DataKi: >2.50E+4nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0NHBPubMed
TargetDelta-type opioid receptor(MOUSE)
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50159165((2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(fura...)copy SMILEScopy InChI
Affinity DataKi: >2.50E+4nMAssay Description:Displacement of [3H]diprenorphine from mouse delta opioid receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0NHBPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402421(CHEMBL2208035)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290819((S)-4-(3-(2H-1,2,3-triazol-2-yl)phenylamino)-2-(1-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50400047(BIIB-057 | CHEMBL2177736 | US9579320, Example 87)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Employing the Milipore panel of purified kinases EXAMPLE 87 (IC50=1 nM) inhibited 98% of purified Syk kinase activity at 50 nM. IC50 values were dete...More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50272192(4-(4-hydroxy-3-methylphenyl)-6-phenylpyrimidin-2(1...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402413(CHEMBL2208032)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402409(CHEMBL2208034)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402412(CHEMBL2208033)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385078(CHEMBL2035629)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385084(CHEMBL2035636)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385075(CHEMBL2035626)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383714(CHEMBL2030402)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50310998(CHEMBL1077458 | N-(4-(2-(4-morpholinophenylamino)p...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383727(CHEMBL2030389)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383736(CHEMBL2030400)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383711(CHEMBL2030387)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of N-terminus His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383740(CHEMBL2030405)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383725(CHEMBL2030386)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383739(CHEMBL2030404)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385076(CHEMBL2035627)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM50396073(CHEMBL1235110)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:SYK tyrosine phosphorylation activity is measured using the LANCE Technology developed by Perkin Elmer Life and Analytical Sciences (Boston, Mass.). ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383711(CHEMBL2030387)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385077(CHEMBL2035628)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402416(CHEMBL2208025)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402424(CHEMBL2208027)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383730(CHEMBL2030393)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383725(CHEMBL2030386)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal His-tagged human PIM1 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50385078(CHEMBL2035629)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal His-tagged human PIM3 expressed in Escherichia coli using AKRRRLSA as substrate after 1 to 2 hrs by luciferasse-luciferin-co...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X34ZHVPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402415(CHEMBL2208028)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50402411(CHEMBL2207759)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ59ZNPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290737(4-(1H-indol-6-ylamino)-2-((1R,2S)-2-aminocyclohexy...)copy SMILES
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290738(2-((1R,2S)-2-aminocyclohexylamino)-4-(quinolin-6-y...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetCell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL
LigandPNGBDBM50383725(CHEMBL2030386)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of N-terminus Myc-tagged human CDC7 expressed in Escherichia coli by chemiluminescence assay in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4WS0PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290627(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290641(4-(3-(1H-pyrazol-1-yl)phenylamino)-2-((1R,2S)-2-am...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290647(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290649(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-2...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290650(2-((1R,2S)-2-aminocyclohexylamino)-4-(3-(thiazol-5...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290809(2-((1R,2S)-2-aminocyclohexylamino)-4-(6-methoxynap...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290831(2-((1R,2S)-2-aminocyclohexylamino)-4-(1-ethyl-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM291025((S)-2-(2-aminobutylamino)-4-(1-ethyl-1H-indol-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290995((R)-2-(2-amino-3-methoxypropylamino)-4-(1-methyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290996((R)-2-(2-amino-3-methylbutylamino)-4-(1-methyl-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290997(2-((2R,3R)-2-amino-3-methoxylbutylamino)-4-(1-ethy...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290998((R)-2-(2-amino-3-ethoxypropylamino)-4-(1-methyl-1H...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Portola Pharmaceuticals, Inc.

US Patent
LigandPNGBDBM290999((R)-2-(2-amino-3-ethoxypropylamino)-4-(1H-indol-4-...)copy SMILES
Affinity DataIC50: 5.5nMpH: 7.5 T: 2°CAssay Description:Potency of candidate molecules for inhibiting syk tyrosine phosphorylation activity is assessed by measuring the ability of a test compound to inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K07692US Patent
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