Compile Data Set for Download or QSAR
Found 80 with Last Name = 'waltenberger' and Initial = 'b'
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50270591(2-(6-chloro-9-(3-hydroxy-3-methylbutyl)-1H-phenant...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168766(3-(1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbipheny...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168776(3-(5-(2'-chloro-2-fluorobiphenyl-4-yl)-1-(4-chloro...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168761(3-(1-(4-chlorobenzyl)-5-(2-fluorobiphenyl-4-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168768(3-(5-(biphenyl-4-yl)-1-(4-chlorobenzyl)-3-methyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343537(5-(4-tert-butylbenzyl)-1-(4-isopropoxyphenyl)-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343535(3-(1-(4-chlorobenzyl)-3-(benzylthio)-5-(2-(4-chlor...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343539(5-(4-tert-butylbenzyl)-3-(4-isopropoxyphenyl)-1-(4...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168771(3-[1-(4-Chloro-benzyl)-3-(3,3-dimethyl-butyryl)-5-...)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 269nMAssay Description:Displacement of estradiol from human ERbetaa expressed in yeast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM7462(3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM32020(4-[4-(3,4-dihydroxyphenyl)-2,3-dimethyl-butyl]pyro...)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50270594(4-(3-chlorobenzyl)-2,6-bis(4-(trifluoromethoxy)phe...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343533(2,2'-(biphenyl-4,4'-diyl)bis(6-chloroquinoline-4-c...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50450896(CHEMBL4210403)copy SMILEScopy InChI
Affinity DataIC50: 780nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343526((Z)-4-(3-((5-(4-Bromophenyl)furan-2-yl)methylene)-...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343530(5,7-dichloro-4-((3-(4-methoxyphenylthio)benzyl)(me...)copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168781(3-[1-(4-Chloro-benzyl)-5-isopropyl-3-(2-methyl-ben...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50216276((-)-dihydroguaiaretic acid | 4,4'-((2R,3R)-2,3-dim...)copy SMILEScopy InChI
Affinity DataIC50: 940nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50450895(CHEMBL4205522)copy SMILEScopy InChI
Affinity DataIC50: 980nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50142192(3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...)copy SMILEScopy InChI
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50450894(CHEMBL4206971)copy SMILEScopy InChI
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343540((R)-2-(4-(biphenyl-4-ylmethylamino)-6-chloropyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50130177(2,6,8-Trihydroxy-10,11-dioxa-benzo[b]fluoren-5-one...)copy SMILEScopy InChI
Affinity DataIC50: 1.52E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM7460(2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-4H-chrome...)copy SMILEScopy InChI
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50339598(2-(3-chloro-4-hydroxyphenyl)-N-phenethylacetamide ...)copy SMILEScopy InChI
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50273441((R)-2-(4-Chloro-6-(4'-cyanobiphenyl-4-ylamino)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50140172(CHEBI:3962 | CHEMBL140 | Curcumin | US9409845, Tab...)copy SMILEScopy InChI
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.87E+3nMAssay Description:Displacement of estradiol from human ERalpha expressed in yeast cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343533(2,2'-(biphenyl-4,4'-diyl)bis(6-chloroquinoline-4-c...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50142192(3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-o...)copy SMILEScopy InChI
Affinity DataIC50: 2.03E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343525(2-(4-bromo-3-(N-p-tolylsulfamoyl)benzamido)benzoic...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343533(2,2'-(biphenyl-4,4'-diyl)bis(6-chloroquinoline-4-c...)copy SMILEScopy InChI
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343536((R)-2-(4-(3,5-bis(2,2,2-trifluoroethoxy)phenylamin...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343528(3-(9-(3-bromo-4-(4-chlorobenzyloxy)phenyl)-3,3,6,6...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343526((Z)-4-(3-((5-(4-Bromophenyl)furan-2-yl)methylene)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50513(4-(2,6-bis(3,4-dimethylphenyl)-1,3,5,7-tetraoxo-1,...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of 5-LO in human polymorphonuclear leukocytes assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 1(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50042944((E)-1-(2,4-Dihydroxy-phenyl)-3-(4-hydroxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.83E+3nMAssay Description:Inhibition of human 17beta-HSD1 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estrone and NADPH by scintillation counting...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343531(2-chloro-5-(4-chloro-2-(3-(3-(trifluoromethyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human recombinant 5-LO in cell-free system assessed as inhibition of LTB4 production after 10 mins by RP-HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343530(5,7-dichloro-4-((3-(4-methoxyphenylthio)benzyl)(me...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50168764(3-[3-tert-Butylsulfanyl-5-isopropyl-1-(3-phenyl-pr...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50339597(CHEMBL589354 | N-benzyl-2-(3-chloro-4-hydroxypheny...)copy SMILEScopy InChI
Affinity DataIC50: 3.42E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
University of Innsbruck

Curated by ChEMBL
LigandPNGBDBM50343532(4-(4-methyl-N-octylphenylsulfonamido)benzoic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of human microsomal PGES1 in cell-free system assessed as inhibition of conversion of PGH2 to PGE2 by HPLC assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MS3T3JPubMed
Target17-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
University of Basel

Curated by ChEMBL
LigandPNGBDBM50133496((2R)-3-(3,4-dihydroxyphenyl)-2-[(2E)-3-(3,4-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 3.72E+3nMAssay Description:Inhibition of human 17beta-HSD2 expressed in HEK293 cell lysates incubated for 10 mins using [2,4,6,7-3H]-estradiol and NAD+ by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD148RPubMed
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