Affinity DataKi: 1nM ΔG°: -50.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 2.90nM ΔG°: -48.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 5.60nM ΔG°: -49.0kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
Affinity DataKi: 5.60nM ΔG°: -46.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 7.80nM ΔG°: -48.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
Affinity DataKi: 15nM ΔG°: -46.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
Affinity DataKi: 16nM ΔG°: -45.2kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
Affinity DataKi: 23nM ΔG°: -43.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 30nM ΔG°: -42.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 41nM ΔG°: -42.9kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
Affinity DataKi: 95nM ΔG°: -39.7kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
Affinity DataKi: 3.60E+3nM ΔG°: -31.6kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 52nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 68nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 92nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 230nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 280nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 560nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation
Curated by ChEMBL
Incyte Corporation
Curated by ChEMBL
Affinity DataIC50: 670nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair