Compile Data Set for Download or QSAR
Found 96 with Last Name = 'zhou' and Initial = 'bb'
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  2.90nM ΔG°:  -48.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -49.0kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  5.60nM ΔG°:  -46.6kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  7.80nM ΔG°:  -48.1kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  15nM ΔG°:  -46.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro Chk1 enzymatic assay using purified enzyme, was incubated with substrate, and test compounds in the presence of 10 uM ATP/ [gamma-32P] ATP. ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  16nM ΔG°:  -45.2kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17140((15R,18R)-28-oxa-4,14,19-triazaoctacyclo[12.11.2.1...)copy SMILEScopy InChI
Affinity DataKi:  23nM ΔG°:  -43.2kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataKi:  41nM ΔG°:  -42.9kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
TargetCyclin-A2/Cyclin-dependent kinase 1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  95nM ΔG°:  -39.7kJ/molepH: 7.4 T: 2°CAssay Description:In vitro CDK enzymatic assay using purified CDK mixed with cyclin A, was incubated with substrate, and test compounds in the presence of 1.4 uM ATP/ ...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM17054((2S,3R,4R,6R,18R)-18-hydroxy-3-methoxy-2-methyl-4-...)copy SMILEScopy InChI
Affinity DataKi:  3.60E+3nM ΔG°:  -31.6kJ/molepH: 7.5 T: 2°CAssay Description:CDK4 and cyclin D1 were expressed in a baculovirus expression system and subsequently purified. The catalytic activity of the CDK4 protein was assaye...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2D798PFPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 92nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203533((6S,7S)-N-hydroxy-6-((R)-3-phenylpyrrolidine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 97nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203526((6S,7S)-6-(4-phenyl-3,6-dihydro-2H-pyridine-1-carb...)copy SMILEScopy InChI
Affinity DataIC50: 113nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203531((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203537((6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203530((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)pi...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203528((6S,7S)-N-hydroxy-5-methyl-6-[(4-phenyl-3,6-dihydr...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203531((6S,7S)-N-hydroxy-6-{[4-(2-methyl-4-nitrophenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203534((6S,7S)-N-hydroxy-5-methyl-6-(4-phenylpiperazine-1...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203537((6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203535((6S,7S)-N-hydroxy-6-(3,4,10,10a-tetrahydropyrazino...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203527((6S,7S)-methyl 7-(hydroxycarbamoyl)-6-(4-phenyl-1,...)copy SMILEScopy InChI
Affinity DataIC50: 428nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203537((6S,7S)-6-(4-phenyl-piperidine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetStromelysin-1(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203538((6S,7S)-6-(3-phenyl-2,5-dihydro-pyrrole-1-carbonyl...)copy SMILEScopy InChI
Affinity DataIC50: 450nMAssay Description:Inhibition of MMP3More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetDisintegrin and metalloproteinase domain-containing protein 10(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203536((2S,3S)-N-hydroxy-2-((R)-3-phenylpyrrolidine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Inhibition of ADAM10More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203536((2S,3S)-N-hydroxy-2-((R)-3-phenylpyrrolidine-1-car...)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50203529((6S,7S)-6-(4-phenyl-piperazine-1-carbonyl)-5-aza-s...)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Inhibition of MMP9More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Incyte Corporation

Curated by ChEMBL
LigandPNGBDBM50082539(1-(4-Methoxy-benzenesulfonyl)-piperidine-2-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 670nMAssay Description:Inhibition of Her2 sheddase activity in BT474 cell lineMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ10P5PubMed
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