Compile Data Set for Download or QSAR
Found 323 with Last Name = 'smith' and Initial = 'br'
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19770((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.00990nM ΔG°:  -62.2kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19770((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.0400nM ΔG°:  -58.8kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.0410nM ΔG°:  -58.7kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin L2(Homo sapiens (Human))
GSK

LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.0630nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.0680nM ΔG°:  -57.4kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19775((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.140nM ΔG°:  -55.7kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.160nM ΔG°:  -55.3kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19775((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  0.630nM ΔG°:  -52.0kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083761(CHEMBL87429 | [3-Oxo-8-[3-(pyridin-2-ylamino)-prop...)copy SMILEScopy InChI
Affinity DataKi:  0.900nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083763(CHEMBL86992 | [(S)-8-[2-(6-Methylamino-pyridin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083764(CHEMBL421533 | [3-Oxo-8-[3-(pyridin-2-ylamino)-pro...)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19780((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  1.40nM ΔG°:  -50.0kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078697(CHEMBL54138 | {(S)-7-[2-(1H-Imidazol-2-ylamino)-et...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q4BPubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19771((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  1.5nM ΔG°:  -49.9kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin S(Homo sapiens (Human))
GSK

LigandPNGBDBM19778((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072493(CHEMBL108490 | [(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Affinity for alphaIIb-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetCathepsin L2(Homo sapiens (Human))
GSK

LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072492(CHEMBL419180 | {(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50083762(CHEMBL314022 | {2-Methyl-3-oxo-8-[3-(pyridin-2-yla...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078710(CHEMBL298782 | {(S)-7-[2-(6-Amino-pyridin-2-ylamin...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q4BPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072468(CHEMBL108685 | {(S)-4-Methyl-7-[methyl-(7-methyl-1...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078696(CHEMBL52026 | {(S)-7-[(2-Amino-3H-imidazol-4-ylmet...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity towards human alpha IIb beta3 integrin by [3H]-RGD peptide displacement.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q4BPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50059133(CHEMBL50106 | SB-223245 | {(S)-7-[(1H-Benzoimidazo...)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Binding affinity towards human Vitronectin receptor.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q4BPubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  2.20nM ΔG°:  -48.9kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19779((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  2.5nM ΔG°:  -48.6kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072504(CHEMBL321648 | [(S)-7-[(1H-Imidazo[4,5-b]pyridin-2...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072483(CHEMBL110517 | {(S)-7-[Bis-(1H-benzoimidazol-2-ylm...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072516(CHEMBL419374 | {(S)-4-(3,3-Dimethyl-butyl)-7-[(1H-...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126595(3-Phenyl-4-{4-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Binding affinity for alphaV-beta5 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072473(CHEMBL110413 | {(S)-7-[(5,6-Difluoro-1H-benzoimida...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Affinity for alphaIIb-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50126595(3-Phenyl-4-{4-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Binding affinity for alphav/beta 3 vitronectin receptor in HEK cellsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-5(Homo sapiens (Human))
GlaxoSmithKline Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  2.60nMAssay Description:Binding affinity for alphaV-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072507(CHEMBL418818 | {(S)-4-Methyl-7-[methyl-(5-methyl-1...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072472(CHEMBL322416 | [(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072509(CHEMBL107927 | {(S)-7-[(1H-Imidazo[4,5-b]pyridin-2...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078703(CHEMBL301760 | {(S)-4-Methyl-3-oxo-7-[2-(pyridin-2...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Binding affinity towards human alpha IIb beta3 integrin by [3H]-RGD peptide displacement.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TT4Q4BPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072474(CHEMBL418999 | {(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  3.5nMAssay Description:Effect against adhesion of HEK 293 cells transfected with human alpha-v beta-3 to vitronectin coated platesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19781((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  3.90nM ΔG°:  -47.5kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin S(Homo sapiens (Human))
GSK

LigandPNGBDBM19769((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetCathepsin K(Homo sapiens (Human))
GSK

LigandPNGBDBM19781((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  4nM ΔG°:  -47.5kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072505(CHEMBL110520 | {(S)-7-[(1H-Imidazo[4,5-b]pyridin-2...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Antagonistic activity for human vitronectin receptor (alphaV-beta3) from plateletsMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B85994PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072498(CHEMBL109003 | {(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50072481(CHEMBL106036 | {(S)-7-[(1H-Benzoimidazol-2-ylmethy...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity evaluated against vitronectin receptor (alphaV-beta3) receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2NG4PSFPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity for Vitronectin receptor (alpha V beta 3)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q290230DPubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
SmithKline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50078714(CHEMBL288493 | SB-265123 | {(S)-3-[3-(Pyridin-2-yl...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Binding affinity for alphaIIb-beta3 vitronectin receptorMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2FN15K8PubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19771((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  4.20nM ΔG°:  -47.3kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
TargetProcathepsin L(Homo sapiens (Human))
GSK

LigandPNGBDBM19780((2S)-2-(1-benzofuran-2-ylformamido)-4-methyl-N-[(4...)copy SMILEScopy InChI
Affinity DataKi:  4.5nM ΔG°:  -47.2kJ/molepH: 5.5 T: 2°CAssay Description:Potential inhibitors were evaluated using the progress curve method. Assays were carried out in the presence of variable concentrations of test compo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SQ8XP5PubMed
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