Compile Data Set for Download or QSAR
Found 613 with Last Name = 'dingwall' and Initial = 'c'
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29782(7,6,5 tricyclic sulfonamide, 22)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26788(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322882(CHEMBL1210359 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29796(sulfonamide tricyclic analogue, 7)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26786(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26788(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29794(sulfonamide tricyclic analogue, 5)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322884(CHEMBL1210361 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26506(BMCL193669 Compound 24 | N-[(2S,3R)-4-[(2,6-dimeth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5SQRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29789(7,6,5 tricyclic sulfonamide, 35)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26506(BMCL193669 Compound 24 | N-[(2S,3R)-4-[(2,6-dimeth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26782(N-[(2S,3R)-1-(3,5-difluorophenyl)-3-hydroxy-4-{[(3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26777(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26776(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26774(3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29815(sulfonamide tricyclic analogue, 28)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322886(CHEMBL1210363 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26773(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-ethoxy-N-[(2S,3...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29770(hydroxyethylamine derivative, 25)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26787(3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1...)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29792(7,6,5 tricyclic sulfonamide, 38)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29777(7,6,5 tricyclic sulfonamide, 15 | BMCL193674 Compo...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29777(7,6,5 tricyclic sulfonamide, 15 | BMCL193674 Compo...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29809(sulfonamide tricyclic analogue, 22)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29805(sulfone tricyclic analogue, 18)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322891(3-(N-(3-cyanophenyl)methylsulfonamido)-N-((2S,3R)-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29781(6,6,5 tricyclic sulfonamide, 21)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26781(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5SQRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29755(hydroxyethylamine derivative, 4)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29804(sulfonamide tricyclic analogue, 15)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29885BRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322888(3-(N-(4-chlorophenyl)methylsulfonamido)-N-((2S,3R)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 2(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50231695(CHEMBL404500 | N-((2S,3R)-4-(4-methoxybenzylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of BACE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67GP2PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26780(3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-4-{[(1...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM10145(lysine sulfonamide analogue 9 | methyl N-[(1S)-1-{...)copy SMILEScopy InChI
Affinity DataIC50: 10nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322914(CHEMBL1210349 | N-((2S,3R)-4-((S)-1-(cyclohexylami...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26775(3-(1,1-dioxo-1,2-thiazinan-2-yl)-N-[(2S,3R)-3-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MC8XBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29800(sulfonamide tricyclic analogue, 11)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322890(CHEMBL1210345 | N-((2S,3R)-4-((S)-1-(cyclohexylami...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
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