Compile Data Set for Download or QSAR
Found 182 with Last Name = 'dix' and Initial = 'c'
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Cardiff University

Curated by ChEMBL
LigandPNGBDBM50411445(CHEMBL235658)copy SMILEScopy InChI
Affinity DataKi:  330nMAssay Description:Inhibition of MK2 in human TERT immortalised HCA2 cells assessed as inhibition of anisomycin-induced HSP27 phosphorylation at 2.5 uM by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095P4PubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50118823(2,2-Dimethyl-propionic acid [5-(7-amino-[1,2,3]tri...)copy SMILEScopy InChI
Affinity DataKi:  1.56E+5nMAssay Description:Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6QWFPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50118822(2,2-Dimethyl-propionic acid [5-(6-amino-8-bromo-pu...)copy SMILEScopy InChI
Affinity DataKi:  5.48E+5nMAssay Description:Ability to inhibit the incorporation of dATP into DNA by DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KS6QWFPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)copy SMILEScopy InChI
Affinity DataIC50: 0.0200nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072289((3S,3aR,6aS)-3-(4-Methyl-2-oxo-pent-3-enyl)-hexahy...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072283((3S,3aR,6aS)-3-Benzyl-hexahydro-cyclopenta[b]furan...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072286((3R,3aR,6aS)-3-Benzyl-hexahydro-cyclopenta[b]furan...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072284((1S,2R,4aR,6aS,6bS,7R,9aS,10aS)-2-Acetoxy-1,4a,6a,...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122920(6-[2-(2,3-Dichloro-phenyl)-imidazo[1,2-a]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072285((3R,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetChymotrypsin-C(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072290((3S,3aR,6aS)-3-Allyl-hexahydro-cyclopenta[b]furan-...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Compound was evaluated for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122915(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122914(6-(2-(2,4-difluorophenyl)imidazo[1,2-a]pyridin-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122916(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50138153(CHEMBL3754283)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated...More data for this Ligand-Target Pair
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50138153(CHEMBL3754283)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122915(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072292((3S,3aS,6aS)-3-Phenylsulfanyl-hexahydro-cyclopenta...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human 6His-TEV-TNIK(1 to 325) expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mins followe...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535491(CHEMBL4558962)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DBTPubMed
TargetMisshapen-like kinase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human full length MINK1(1-1332)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubate...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122914(6-(2-(2,4-difluorophenyl)imidazo[1,2-a]pyridin-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122908(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122922(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMisshapen-like kinase 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50138153(CHEMBL3754283)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human full length MINK1(1-1332)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubate...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50269526((1S,2R,4aR,4bR,6aS,6bS,7R,9aS,10aS,12aR)-2-Acetoxy...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human thrombin by fibrinogen-clot assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63MQ2PubMed
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072287((3S,6aS)-3-(4-Methyl-2-oxo-pent-3-enyl)-hexahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122916(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50138153(CHEMBL3754283)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human full length MAP4K4(1-1239)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubat...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human full length MAP4K4(1-1239)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubat...More data for this Ligand-Target Pair
TargetProthrombin(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072289((3S,3aR,6aS)-3-(4-Methyl-2-oxo-pent-3-enyl)-hexahy...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of thrombinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122920(6-[2-(2,3-Dichloro-phenyl)-imidazo[1,2-a]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM15244(5-(2,6-dichlorophenyl)-2-(2,4-difluorophenyl)sulfa...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122918(2-(2,6-Dichloro-phenyl)-6-[2-(2,4-difluoro-phenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122908(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of Tumor necrosis factor alpha release from LPS-induced THP-1 cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535491(CHEMBL4558962)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human full length MAP4K4(1-1239)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DBTPubMed
TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122913(6-[2-(2,4-Difluoro-phenyl)-imidazo[1,2-a]pyridin-3...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Tested in vitro for filter plate binding versus gamma-[33P]ATP in active recombinant murine FLAG-P38 alpha fusion protein (GST-Activating transcripti...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072290((3S,3aR,6aS)-3-Allyl-hexahydro-cyclopenta[b]furan-...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetMitogen-activated protein kinase 11(Mus musculus (mouse))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50122916(6-[2-(2-Chloro-4-fluoro-phenyl)-imidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Displacement of [gamma-33P]-ATP binding from active recombinant murine FLAG-Mitogen-activated protein kinase p38 beta fusion protein (GST-ATF2)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8XRRPubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Sardar Patel University

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)copy SMILEScopy InChI
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8GC0PubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Sardar Patel University

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)copy SMILEScopy InChI
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate incubated for 2 mins followed by substrate additionMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26T0R0VPubMed
TargetDihydrofolate reductase(Bos taurus (Cattle))
Sardar Patel University

Curated by ChEMBL
LigandPNGBDBM22985(Aralen | CHEMBL76 | CHLOROQUINE PHOSPHATE | Chloro...)copy SMILEScopy InChI
Affinity DataIC50: 31.3nMAssay Description:Inhibition of bovine liver DHFR using FH2 as substrate preincubated for 2 mins followed by substrate addition in presence of NADPHMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TX3HN7PubMed
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535489(CHEMBL4471729)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 4(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50138153(CHEMBL3754283)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human 6His-TEV-SHM-MAP4K4(2 to 328)-GNS expressed in baculovirus-infected sf21 cells using LRRKtide as substrate preincubated for 30 mi...More data for this Ligand-Target Pair
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072287((3S,6aS)-3-(4-Methyl-2-oxo-pent-3-enyl)-hexahydro-...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetChymotrypsin-C(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072282((3R,3aR,6aS)-3-Allyl-hexahydro-cyclopenta[b]furan-...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Compound was evaluated for the inhibition of ChymotrypsinogenMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
TargetTRAF2 and NCK-interacting protein kinase(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50535491(CHEMBL4558962)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human full length TNIK(1-1360)-G5-Avi-6His-Flag expressed in baculovirus-infected sf21 cells using His6-SMAD1 as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DBTPubMed
TargetSerine protease 1(Homo sapiens (Human))
GlaxoWellcome Research and Development

Curated by ChEMBL
LigandPNGBDBM50072293(5-((3R,3aR,6aS)-2-Oxo-hexahydro-cyclopenta[b]furan...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ105FPubMed
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