Compile Data Set for Download or QSAR
Found 372 with Last Name = 'howes' and Initial = 'c'
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25771(1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-ph...)copy SMILEScopy InChI
Affinity DataKi:  0.390nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318156(CHEMBL1094785 | carmoterol)copy SMILEScopy InChI
Affinity DataKi:  3.20nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50151720(ARFORMOTEROL TARTRATE | CHEMBL1363 | CHEMBL605993 ...)copy SMILEScopy InChI
Affinity DataKi:  23nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318159(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-y...)copy SMILEScopy InChI
Affinity DataKi:  76nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMedDrugBank
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318157(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-di-n-butylindan-...)copy SMILEScopy InChI
Affinity DataKi:  112nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318158(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-di-n-propylindan...)copy SMILEScopy InChI
Affinity DataKi:  119nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318161(8-Hydroxy-5-[(R)-1-hydroxy-2-(indan-2-ylamino)-eth...)copy SMILEScopy InChI
Affinity DataKi:  218nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318155(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethoxyindan-2...)copy SMILEScopy InChI
Affinity DataKi:  342nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318160(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethylindan-2-...)copy SMILEScopy InChI
Affinity DataKi:  522nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318154(8-Hydroxy-5-[(R)-1-hydroxy-2-(4,7-diethylindan-2-y...)copy SMILEScopy InChI
Affinity DataKi:  692nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25769(4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxym...)copy SMILEScopy InChI
Affinity DataKi:  1.83E+3nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50313618(1-(3-chlorophenyl)-3-(piperidin-2-ylmethyl)imidazo...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8ZJGPubMed
TargetAdenosine receptor A1(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)copy SMILEScopy InChI
Affinity DataKi:  2.30E+3nMAssay Description:Inhibition of adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50313619(2-((3-phenylimidazolidin-1-yl)methyl)piperidine | ...)copy SMILEScopy InChI
Affinity DataKi:  2.51E+3nMAssay Description:Activity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8ZJGPubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318153((2S,3S,4S,5R,6S)-6-(5-((R)-2-(5,6-diethyl-2,3-dihy...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [125I]cyanopindolol from human recombinant beta2 adrenergic receptor expressed in CHO cells by filtration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318156(CHEMBL1094785 | carmoterol)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50151720(ARFORMOTEROL TARTRATE | CHEMBL1363 | CHEMBL605993 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318161(8-Hydroxy-5-[(R)-1-hydroxy-2-(indan-2-ylamino)-eth...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207120(3-isobutyl-8-((6-methoxyisoquinolin-4-yl)methyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26788(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-2-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207130(8-((6,7-dimethoxy-1-methylisoquinolin-4-yl)methyl)...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26503(3-ethyl-N-[(2S,3R)-3-hydroxy-1-phenyl-4-({[3-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318155(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-dimethoxyindan-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322883(3-ethoxy-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(trifl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322882(CHEMBL1210359 | N-((1S,2R)-3-(((1S)-2-(CYCLOHEXYLA...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM25771(1-hydroxy-2-naphthoic acid;4-[1-hydroxy-2-[6-(4-ph...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322916(3-cyclopentyl-N-((2S,3R)-3-hydroxy-1-phenyl-4-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29796(sulfonamide tricyclic analogue, 7)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29794(sulfonamide tricyclic analogue, 5)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29815(sulfonamide tricyclic analogue, 28)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26502(3-(1,1-dioxo-1,2-thiazinan-2-yl)-5-(ethylamino)-N-...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322884(CHEMBL1210361 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26506(BMCL193669 Compound 24 | N-[(2S,3R)-4-[(2,6-dimeth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5SQRPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207121(CHEMBL245648 | N-(4-((8-((6,7-dimethoxyisoquinolin...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29770(hydroxyethylamine derivative, 25)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322886(CHEMBL1210363 | N-((2S,3R)-3-hydroxy-1-phenyl-4-(3...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207123(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-(3-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29777(7,6,5 tricyclic sulfonamide, 15 | BMCL193674 Compo...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-2 adrenergic receptor(GUINEA PIG)
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50318159(8-Hydroxy-5-[(R)-1-hydroxy-2-(5,6-diethylindan-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Agonist activity at beta2 adrenergic receptor in guinea pig tracheal strip assessed as inhibition of electrically-induced bronchocontractile response...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1JRTPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29805(sulfone tricyclic analogue, 18)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM50322891(3-(N-(3-cyanophenyl)methylsulfonamido)-N-((2S,3R)-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RB75K7PubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207127(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-1-methyl...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29809(sulfonamide tricyclic analogue, 22)copy SMILEScopy InChI
Affinity DataIC50: 8nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29804(sulfonamide tricyclic analogue, 15)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25H7DKKPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM29755(hydroxyethylamine derivative, 4)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F18X23PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
GSK

LigandPNGBDBM26508(BMCL193669 Compound 26 | N-[(2S,3R)-4-(cyclohexyla...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 4.5 T: 2°CAssay Description:Enzyme activity and inhibition were assayed using a fluorescent FAM-[SEVNLDAEFK]-TAMRA substrate. Control reactions with no enzyme were included in e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XS5SQRPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Novartis Institutes of Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50207132(8-((6,7-dimethoxyisoquinolin-4-yl)methyl)-3-isobut...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human platelet PDE5 by [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X63NSCPubMed
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