Compile Data Set for Download or QSAR
Found 16 with Last Name = 'mannino' and Initial = 'c'
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.49E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.49E+5nM Kd:  1.54E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29017((1S,5S,7R)-N-hydroxy-3-[(4-phenylphenyl)methyl]-6,...)copy SMILEScopy InChI
Affinity DataIC50: 3.99E+5nM Kd: >5.00E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29016((1R,5S,7R)-N-hydroxy-2-oxo-3-[(4-phenylphenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.25E+5nM Kd: >5.00E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 5.13E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetCollagenase 3(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 7.78E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29015((1S,5S,7R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-...)copy SMILEScopy InChI
Affinity DataIC50: 8.35E+5nM Kd: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetStromelysin-2(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 8.65E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29014((1R,5S,7R)-2-oxo-3-[(4-phenylphenyl)methyl]-6,8-di...)copy SMILEScopy InChI
Affinity DataIC50: 9.54E+5nM Kd: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.18E+6nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMatrilysin(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.51E+6nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29023((1S,5R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-aza...)copy SMILEScopy InChI
Affinity DatapH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29020((1S,5S,7R)-3-benzyl-6,8-dioxa-3-azabicyclo[3.2.1]o...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29022(ethyl 1-(hydroxycarbamoyl)piperidine-4-carboxylate...)copy SMILEScopy InChI
Affinity DataKd:  3.40E+6nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29021((1R,5S,7R)-3-benzyl-N-hydroxy-2-oxo-6,8-dioxa-3-az...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University of Florence

LigandPNGBDBM29019((1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3...)copy SMILEScopy InChI
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9VPXPubMed