Compile Data Set for Download or QSAR
Found 35 with Last Name = 'nye' and Initial = 'c'
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50062938(CHEMBL3397909 | N-[(3S)-1-Acryloyl-3-pyrrolidinyl]...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213220(N-[(3S)-1-Acryloyl-3-pyrrolidinyl]-4-{[cis-2,6-dim...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213221((S)-1-(3-((4-(Piperidin-1-ylmethyl)-6-(thiazolo[5,...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213223(1-((S)-3-((4-((((R)-3,3-Dimethylbutan-2-yl)amino)m...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213219((S)-1-(3-((4-(Morpholinomethyl)-6-(thiazolo[5,4-b]...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213222((S)-1-(3-((4-((Dimethylamino)methyl)-6-(thiazolo[5...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213226(N-{(3S)-1-[(2E)-2-Butenoyl]-3-pyrrolidinyl}-4-{[ci...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213212((trans)-4-((4-(Morpholinomethyl)-6-(thiazolo[5,4-b...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213219((S)-1-(3-((4-(Morpholinomethyl)-6-(thiazolo[5,4-b]...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213217(N-(cis-3-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazol...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213215(N-(cis-2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazol...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213214(N2-(1-Acryloyl-4-piperidinyl)-6-(4-morpholinylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213218(N2-[(3S)-1-Acryloyl-3-pyrrolidinyl]-6-(4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50005480((-)-combretastatin | (Z)-3'-hydroxy-3,4,4',5-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213213(N-(2-{[4-(4-Morpholinylmethyl)-6-([1,3]thiazolo[5,...)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+3nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213216(N-(trans-4-{[4-(4-Morpholinylmethyl)-6-([1,3]thiaz...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetTyrosine-protein kinase ITK/TSK [357-620,Y512E](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM213224(N2-[(3R)-1-Acryloyl-3-pyrrolidinyl]-6-(4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:This assay is based on the binding and displacement of Alexa-fluor 647-labeled ATP-competitive kinase inhibitor tracer 236. Binding of the tracer is ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZW1JSKPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055045(CHEMBL3323243)copy SMILEScopy InChI
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055045(CHEMBL3323243)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055046(CHEMBL3323245)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055044(CHEMBL3323241)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50424716(NOSCAPINE | Narcotine | Tusscapine)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055043(CHEMBL3323244)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055046(CHEMBL3323245)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055043(CHEMBL3323244)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Displacement of [3H]colchicine from bovine brain tubulin assessed as rate of assembly after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055041(CHEMBL3323240)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Displacement of [3H]colchicine from bovine brain tubulin assessed as rate of assembly after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055041(CHEMBL3323240)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055042(CHEMBL3323242)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055042(CHEMBL3323242)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Displacement of [3H]colchicine from bovine brain tubulin assessed as rate of assembly after 10 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055043(CHEMBL3323244)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055044(CHEMBL3323241)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055042(CHEMBL3323242)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as extent of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed
TargetSimilar to alpha-tubulin isoform 1(Bos taurus)
University of Padova

Curated by ChEMBL
LigandPNGBDBM50055041(CHEMBL3323240)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+5nMAssay Description:Inhibition of bovine brain tubulin assessed as rate of assembly preincubated for 15 mins by turbidimetryMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5QGDPubMed