Compile Data Set for Download or QSAR
Found 463 with Last Name = 'pergola' and Initial = 'c'
TargetHistone deacetylase(Homo sapiens (Human))
Mashhad University of Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50005711(CHEBI:46024 | GNF-Pf-1011 | TRICHOSTATIN | Trichos...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of HDAC in human HeLa cell nuclear extract using BML-KI104 Fluor de Lys as substrate by fluorescence-based assayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308732(CHEMBL605820 | Isopropyl-2-methyl-5-[4-(methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50224129(CHEMBL237626 | ethyl-2-methyl-5-[4-(methylsulfonyl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0FV8PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50224118(CHEMBL237592 | ethyl-2-methyl-5-[4-(methylsulfonyl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0FV8PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308736(CHEMBL602237 | n-Butyl-2-Methyl-5-[4-(methylsulfon...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262934(CHEMBL477362 | [3-(2-Ethoxyethyl)-2-methyl-5-(4-me...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262990(CHEMBL517675 | [2-Methyl-5-(4-methylsulphonyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262933(CHEMBL451358 | [1-(4-Fluoro)phenyl-2-methyl-5-(4-m...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50224128(CHEMBL238027 | ethyl-2-methyl-5-[4-(methylsulfonyl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0FV8PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308738(CHEMBL589813 | Isopropyl-2-methyl-5-[4-(methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308740(CHEMBL600167 | Isopropyl-2-methyl-5-[4-(methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308737(CHEMBL600844 | n-Butyl-2-methyl-5-[4-(methylsulfon...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50224122(CHEMBL398382 | ethyl-2-methyl-5-[4-(methylsulfonyl...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0FV8PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308735(2-Methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262992(CHEMBL479054 | [1-(4-Fluoro)phenyl-2-methyl-5-(4-m...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308739(CHEMBL589087 | n-Butyl-2-methyl-5-[4-(methylsulfon...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31134(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11m)copy SMILEScopy InChI
Affinity DataIC50: 31nM EC50:  490nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308741(CHEMBL589166 | n-Butyl-2-methyl-5-[4-(methylsulfon...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50166278(CHEMBL191941 | [5-(4-Methanesulfonyl-phenyl)-2-met...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50166278(CHEMBL191941 | [5-(4-Methanesulfonyl-phenyl)-2-met...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50308734(CHEMBL589812 | Isopropyl-2-methyl-5-[4-(methylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X291DPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31132(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11k)copy SMILEScopy InChI
Affinity DataIC50: 45nM EC50:  520nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262989(CHEMBL476536 | [3-(2-Ethoxyethyl)-1-(4-Fluoro)phen...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262931(CHEMBL516289 | [2-Methyl-5-(4-methylsulphonyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31135(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11n)copy SMILEScopy InChI
Affinity DataIC50: 49nM EC50:  2.80E+3nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262932(CHEMBL478415 | [2-Methyl-5-(4-methylsulphonyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50166281(CHEMBL192789 | [5-(4-Methanesulfonyl-phenyl)-2-met...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31133(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11l)copy SMILEScopy InChI
Affinity DataIC50: 67nM EC50:  320nMAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253541((-)-(R)-Ethyl-[2-hydroxy-2-[1-(3-fluoro)phenyl-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253543((+)-(S)-Ethyl-[2-hydroxy-2-[1-(4-methoxy)phenyl-2-...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of COX2-dependent PGE2 production in LPS-stimulated mouse J774 cells by RIAMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1K62PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31124(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11c)copy SMILEScopy InChI
Affinity DataIC50: 84nM EC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262935(CHEMBL515478 | [3-(2-Ethoxyethyl)-2-methyl-5-(4-me...)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31122(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11a)copy SMILEScopy InChI
Affinity DataIC50: 86nM EC50:  230nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253627((-)-(R)-Ethyl-[2-ethoxy-2-[1-(4-methoxy)phenyl-2-m...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM50006805(3-(1-(4-chlorobenzyl)-3-(tert-butylthio)-5-isoprop...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of 5-lipoxygenase in A23187-stimulated human PMNL assessed as enzyme product formation preincubated 15 mins by RP-HPLC analysis in presenc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1K62PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31128(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11g)copy SMILEScopy InChI
Affinity DataIC50: 95nM EC50:  600nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31126(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11e)copy SMILEScopy InChI
Affinity DataIC50: 96nM EC50:  500nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich Alexander University Erlangen

LigandPNGBDBM31123(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11b)copy SMILEScopy InChI
Affinity DataIC50: 97nM EC50:  1.20E+3nMpH: 7.4 T: 2°CAssay Description:For determination of the activity of 5-LO in 40000g supernatant (S40), aliquots of the supernatants were added to reaction mix, and were preincubated...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM56S5PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253569((+/-)-Ethyl-[2-ethoxy-2-[1-(3-fluoro)phenyl-2-meth...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
TargetProstaglandin E synthase(Homo sapiens (Human))
Eberhard Karls University Tuebingen

Curated by ChEMBL
LigandPNGBDBM31123(5-hydroxy-1H-benzo[g]indole-3-carboxylate, 11b)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of mPGES1 in IL1beta induced human A549 cell microsomal membrane assessed as blockade of conversion of PGH2 to PGE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25T3KK7PubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253567((+)-(S)-Ethyl-[2-ethoxy-2-[-2-methyl-5-(4-methylsu...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM22334(BW A4C | BW4C | BWA4C | BWA4C, 10 | CHEMBL314360 |...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JFMPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50262991(CHEMBL479053 | [2-Methyl-5-(4-methylsulphonyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of mouse COX2 in LPS-stimulated mouse J774 cells assessed as PGE2 production by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KH0N55PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Gazi University

Curated by ChEMBL
LigandPNGBDBM50385376(CHEMBL2036377)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of FLAP in A23187-stimulated human neutrophils assessed as 5-LO product formation preincubated for 15 mins measured after 10 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4JFMPubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Universit£ La Sapienza

Curated by ChEMBL
LigandPNGBDBM50253489((+/-)-Ethyl-[2-hydroxy-2-[1-(3-fluoro)phenyl-2-met...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of COX2 in LPS-stimulated mouse J774 cells assessed as inhibition of PGE2 production after 15 mins by radioimmunoassayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24J0DZWPubMed
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