Compile Data Set for Download or QSAR
Found 266 with Last Name = 'steppan' and Initial = 'c'
TargetReplicase polyprotein 1ab(BtCoV)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.0330nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(BtCoV)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.0340nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(Feline coronavirus (strain FIPV WSU-79/1146) (FCoV...)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.270nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.270nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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TargetReplicase polyprotein 1ab(PEDV)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(HCoV-OC43)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.510nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(BtCoV)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.740nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(HCoV-NL63)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.770nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(HCoV-HKU1)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  0.850nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(MHV-A59)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(HCoV-229E)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  1.5nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)copy SMILEScopy InChI
Affinity DataKi:  3.11nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(IBV)
Pfizer Inc.

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:PF-00835231 was evaluated against 3CLpro from a variety of other coronaviruses representing alpha, beta and gamma groups of Coronaviridae, using bioc...More data for this Ligand-Target Pair
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In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ352QPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496900(science.abl4784, 4)copy SMILEScopy InChI
Affinity DataKi:  7.93nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9MCM
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496901(science.abl4784, 5)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9MCM
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496896(US11312704, Compound 101 | US11351149, Example 49 ...)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9MCM
TargetReplicase polyprotein 1ab(2019-nCoV)
Pfizer

LigandPNGBDBM496897(science.abl4784, 3)copy SMILEScopy InChI
Affinity DataKi:  230nMAssay Description:The respective human coronavirus Mpro in assay buffer (20 mM Tris-HCl, pH 7.3, 100 mM NaCl, 1 mM EDTA, 5 mM TCEP) and 0.1% BSA was added to assay-rea...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9MCM
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))TBA
LigandPNGBDBM50581623(CHEMBL5088467)copy SMILES
Affinity DataKi:  400nMAssay Description:Antagonist activity at muscarinic M1 receptor (unknown origin) expressed in cells assessed as change in fluorescence measured after 24 hrs by FLIPR a...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15JRPubMed
LigandPNGBDBM50581623(CHEMBL5088467)copy SMILES
Affinity DataKi:  7.20E+3nMAssay Description:Displacement of [3H]-dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD15JRPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM223332(US9315520, 19 | US9605007, Example 19 | US9744173,...)copy SMILEScopy InChI
Affinity DataIC50: 0.0140nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50452875(CHEMBL4212046)copy SMILEScopy InChI
Affinity DataIC50: 0.0330nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50452884(CHEMBL4217023)copy SMILEScopy InChI
Affinity DataIC50: 0.0340nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50452883(CHEMBL4203860)copy SMILEScopy InChI
Affinity DataIC50: 0.110nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM143218(US8940748, 34 | US9029362, 34 | US9687494, 34)copy SMILEScopy InChI
Affinity DataIC50: 0.540nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50452874(CHEMBL4217620)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM312938(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.877nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ880HPubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50342887((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-methoxybenzyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 0.882nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ880HPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM143218(US8940748, 34 | US9029362, 34 | US9687494, 34)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50452874(CHEMBL4217620)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of human BACE2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50308469((2S,3R,4R,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6RBPPubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50342889((1S,2S,3S,4R,5S)-1-(Hydroxymethyl)-5-[3-(4-methoxy...)copy SMILEScopy InChI
Affinity DataIC50: 1.07nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ880HPubMed
TargetSolute carrier family 5 member 4(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50342888((1S,2S,3S,4R,5S)-5-[3-(4-Ethoxybenzyl)-4-methylphe...)copy SMILEScopy InChI
Affinity DataIC50: 1.11nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of methyl alpha-D-glucopyranoside uptake after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ880HPubMed
TargetSodium/glucose cotransporter 2(Rattus norvegicus)
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM50342885((1S,2S,3S,4R,5S)-5-[4-Chloro-3-(4-ethoxybenzyl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 1.15nMAssay Description:Inhibition of rat SGLT2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NZ880HPubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM20880((2S,3R,4R,5S,6R)-2-{4-chloro-3-[(4-ethoxyphenyl)me...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50313364((2S,3R,4R,5S,6R)-2-(3-(4-ethylbenzyl)-4-methylphen...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6RBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM143218(US8940748, 34 | US9029362, 34 | US9687494, 34)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human BACE1 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM47353(BDBM143220 | US9029362, 173 | US9687494, 25)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50313371((2S,3R,4S,5S,6R)-2-(4-chloro-3-(4-methoxybenzyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6RBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM223400(US9315520, 45 | US9315520, Example 45 | US9605007,...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50313374((5S,6R,7R,8S)-5-(3-(4-ethylbenzyl)-4-methylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6RBPPubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM143218(US8940748, 34 | US9029362, 34 | US9687494, 34)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Displacement of [3H]-PF-6475886 from recombinant human full length Myc-DDK-tagged BACE2 expressed in HEK293 cell membranes after 30 mins by parallel ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetSodium/glucose cotransporter 2(Homo sapiens (Human))
Pfizer Global Research& Development

Curated by ChEMBL
LigandPNGBDBM50313367((6S,7R,8R,9S)-6-(3-(4-ethylbenzyl)-4-methylphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human SGLT2 expressed in CHO cells assessed as inhibition of sodium-dependent methyl-alpha-D-[U-14C]glucopyranoside uptake after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DF6RBPPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM223396(US9315520, 7 | US9315520, Example 7 | US9605007, E...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM312940(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM312938(N-{2-[(4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetra...)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human BACE2 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM143218(US8940748, 34 | US9029362, 34 | US9687494, 34)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of human BACE2 using biotin-GLTNIKTEEISEISYEVEFR-C[Oregon green]KK-OH as substrate after 3 hrs by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Pfizer Inc.

Curated by ChEMBL
LigandPNGBDBM223330(US9315520, 17 | US9605007, Example 17 | US9744173,...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with wild type APP assessed as reduction in soluble portion of APPbeta level in cells incubated for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3GJ5PubMed
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