Compile Data Set for Download or QSAR
Found 5061 with Last Name = 'strain-damerell' and Initial = 'c'
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)copy SMILEScopy InChI
Affinity DataKi:  1.97E+3nMAssay Description:Competitive inhibition of human KDM2A expressed in Escherichia coli using 2-oxoglutarate by enzyme kinetic assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3N9SPubMed
TargetLysine-specific demethylase 2A(Homo sapiens (Human))
University of Oxford

Curated by ChEMBL
LigandPNGBDBM50395076(CHEMBL2164243)copy SMILEScopy InChI
Affinity DataKi:  8.50E+4nMAssay Description:Mixed type inhibition of human KDM2A expressed in Escherichia coli assessed inhibition constant for compound-enzyme-substrate complex using methyl ly...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JH3N9SPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMMore data for this Ligand-Target Pair
Ligand InfoPurchaseMCE
PDB
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)copy SMILEScopy InChI
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8X6KPubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetLysine-specific demethylase 5A [1-801](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8X6KPubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetLysine-specific demethylase 5C [1-765](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 13nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8X6KPubMed
TargetLysine-specific demethylase 5D [1-775](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 15nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8X6KPubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496478(LOR-NOR-30067bb9-11)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM223320(KDOAM-25)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM223320(KDOAM-25)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetLysine-specific demethylase 5D(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495599(CVD-0016335 | STE-KUL-d79e3d6a-3)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495599(CVD-0016335 | STE-KUL-d79e3d6a-3)copy SMILEScopy InChI
Affinity DataIC50: 21nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetLysine-specific demethylase 5A [1-801](Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P8X6KPubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM195612(GSK467)copy SMILEScopy InChI
Affinity DataIC50: 26nMpH: 7.5Assay Description:The demethylase AlphaScreen assay was performed in 384-well plate format using white proxiplates (PerkinElmer), and transfer of compound (100 nl) was...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496258(CVD-0013146 | JOH-MSK-46727e7b-1)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM496258(CVD-0013146 | JOH-MSK-46727e7b-1)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495290(CVD-0018692 | MAT-POS-e194df51-1)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495803(CVD-0015332 | MAT-POS-e69ad64a-2)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495803(CVD-0015332 | MAT-POS-e69ad64a-2)copy SMILEScopy InChI
Affinity DataIC50: 42nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495598(CVD-0016334 | STE-KUL-d79e3d6a-2)copy SMILEScopy InChI
Affinity DataIC50: 44nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495598(CVD-0016334 | STE-KUL-d79e3d6a-2)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM495783(MAT-POS-f9802937-8)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)copy SMILEScopy InChI
Affinity DataIC50: 49nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM429304(CVD-0006354 | acs.jmedchem.1c00409_ST.426 | indole...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MS3WV7
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
University of Oxford

LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:We previously described 4-carboxy-2-triazolopyridines as selective KDM2 inhibitors (England et al., 2014). In efforts to find alternative scaffolds b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2288PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)TBA
LigandPNGBDBM429304(CVD-0006354 | acs.jmedchem.1c00409_ST.426 | indole...)copy SMILEScopy InChI
Affinity DataIC50: 50nMMore data for this Ligand-Target Pair
In DepthDetails
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