Compile Data Set for Download or QSAR
Found 121 with Last Name = 'tomooka' and Initial = 'c'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499195(CHEMBL3735504)copy SMILEScopy InChI
Affinity DataKi:  0.340nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499203(CHEMBL3736036)copy SMILEScopy InChI
Affinity DataKi:  0.420nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499205(CHEMBL3734814)copy SMILEScopy InChI
Affinity DataKi:  0.480nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499208(CHEMBL3734872)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499194(CHEMBL3734854)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499197(CHEMBL3736465)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499206(CHEMBL3735949)copy SMILEScopy InChI
Affinity DataKi:  1.60nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499198(CHEMBL3736278)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499199(CHEMBL3735673)copy SMILEScopy InChI
Affinity DataKi:  2.80nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499202(CHEMBL3735523)copy SMILEScopy InChI
Affinity DataKi:  3.80nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499200(CHEMBL3735044)copy SMILEScopy InChI
Affinity DataKi:  6.40nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499210(CHEMBL3734846)copy SMILEScopy InChI
Affinity DataKi:  6.5nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499211(CHEMBL3735247)copy SMILEScopy InChI
Affinity DataKi:  7.80nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499204(CHEMBL3735719)copy SMILEScopy InChI
Affinity DataKi:  8.20nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499207(CHEMBL3735975)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499201(CHEMBL3736469)copy SMILEScopy InChI
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499197(CHEMBL3736465)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499199(CHEMBL3735673)copy SMILEScopy InChI
Affinity DataKi:  15nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499199(CHEMBL3735673)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499194(CHEMBL3734854)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499209(CHEMBL3735096)copy SMILEScopy InChI
Affinity DataKi:  39nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499194(CHEMBL3734854)copy SMILEScopy InChI
Affinity DataKi:  48nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499203(CHEMBL3736036)copy SMILEScopy InChI
Affinity DataKi:  72nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499203(CHEMBL3736036)copy SMILEScopy InChI
Affinity DataKi:  130nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499204(CHEMBL3735719)copy SMILEScopy InChI
Affinity DataKi:  374nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499198(CHEMBL3736278)copy SMILEScopy InChI
Affinity DataKi:  608nMAssay Description:Inhibition of IRAK-1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499197(CHEMBL3736465)copy SMILEScopy InChI
Affinity DataKi:  700nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499204(CHEMBL3735719)copy SMILEScopy InChI
Affinity DataKi:  800nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499205(CHEMBL3734814)copy SMILEScopy InChI
Affinity DataKi:  1.30E+3nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499198(CHEMBL3736278)copy SMILEScopy InChI
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50499195(CHEMBL3735504)copy SMILEScopy InChI
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50184719(CHEMBL208116 | N-(5-fluoro-1H-benzo[d]imidazol-2-y...)copy SMILEScopy InChI
Affinity DataKi:  4.50E+3nMAssay Description:Inhibition of recombinant full length IRAK-4 (unknown origin) using the biotinylated substrate RRRVTSPARRS by chemiluminescent ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0JG8PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32573(CHEMBL427896 | arylsulfonylpiperazine, 45)copy SMILEScopy InChI
Affinity DataIC50: 3nM EC50:  57nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32566(arylsulfonylpiperazine, 38)copy SMILEScopy InChI
Affinity DataIC50: 3nM EC50:  315nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen Inc.

LigandPNGBDBM32567(arylsulfonylpiperazine, 39)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32538(arylsulfonylpiperazine, 10)copy SMILEScopy InChI
Affinity DataIC50: 4nM EC50:  201nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen Inc.

LigandPNGBDBM32571(arylsulfonylpiperazine, 43)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen Inc.

LigandPNGBDBM32568(arylsulfonylpiperazine, 40)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32550(arylsulfonylpiperazine, 22)copy SMILEScopy InChI
Affinity DataIC50: 7nM EC50:  241nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32567(arylsulfonylpiperazine, 39)copy SMILEScopy InChI
Affinity DataIC50: 9nM EC50:  632nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32572(arylsulfonylpiperazine, 44)copy SMILEScopy InChI
Affinity DataIC50: 9nM EC50:  569nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen Inc.

LigandPNGBDBM32570(arylsulfonylpiperazine, 42)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32561(arylsulfonylpiperazine, 33)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  247nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Amgen Inc.

LigandPNGBDBM32546(arylsulfonylpiperazine, 18)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Enzyme assays were performed using purified recombinant mouse11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine en...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32571(arylsulfonylpiperazine, 43)copy SMILEScopy InChI
Affinity DataIC50: 11nM EC50:  762nMAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32546(arylsulfonylpiperazine, 18)copy SMILEScopy InChI
Affinity DataIC50: 13nM EC50:  547nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32547(arylsulfonylpiperazine, 19)copy SMILEScopy InChI
Affinity DataIC50: 13nM EC50:  329nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32540(arylsulfonylpiperazine, 12)copy SMILEScopy InChI
Affinity DataIC50: 14nM EC50:  518nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32541(arylsulfonylpiperazine, 13)copy SMILEScopy InChI
Affinity DataIC50: 14nM EC50:  727nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [24-292,C272S](Homo sapiens (Human))
Amgen Inc.

LigandPNGBDBM32556(arylsulfonylpiperazine, 28)copy SMILEScopy InChI
Affinity DataIC50: 15nM EC50:  971nMpH: 7.2 T: 2°CAssay Description:Enzyme assays were performed using purified recombinant human 11beta-HSD1. The fractional conversion of cortisone to cortisol was used to determine e...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J964Q1PubMed
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