TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of PKCzeta (unknown origin) by TR-FRET based lanthascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 530nMAssay Description:Inhibition of PKCzeta (unknown origin) by TR-FRET based lanthascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 539nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 824nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.21E+3nMAssay Description:Inhibition of PKCzeta (unknown origin) by TR-FRET based lanthascreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.29E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of PKCzeta (unknown origin) by TR-FRET based lanthascreen assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of Mitogen-activated protein kinase (MAPK)phosphorylation by activated MEK-1More data for this Ligand-Target Pair
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of MEK1 phosphorylation by activated human recombinant RafMore data for this Ligand-Target Pair
Affinity DataIC50: 1.13E+4nMAssay Description:Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.27E+4nMAssay Description:Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.69E+4nMAssay Description:Inhibition of Epidermal growth factor receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90E+4nMAssay Description:Inhibition of HIV-1 integrase by colorimetryMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+4nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 8.70E+4nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.08E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.36E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.56E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.87E+5nMAssay Description:Inhibition of full-length wild-type cystathionine beta-synthase (unknown origin) assessed as inhibition of H2S production by fluorescence assay in pr...More data for this Ligand-Target Pair
Affinity DataIC50: 2.42E+5nMAssay Description:Inhibition of insulin receptor mediated mitogenesis of NIH3T3 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+7nMAssay Description:Inhibition of HIV-1 integrase by colorimetryMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of IL1-induced NFkappaB P65 activation in human osteoarthritic primary chondrocytes preincubated 2 hrs before addition of IL1 by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of IL1-induced NFkappaB P65 activation in human osteoarthritic primary chondrocytes preincubated 2 hrs before addition of IL1 by ELISAMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataEC50: 6.00E+3nMAssay Description:Inhibition of hypoxia-induced HIF1 transcriptional activation in human U251-HRE cells by luciferase reporter assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataEC50: 8.00E+3nMAssay Description:Inhibition of hypoxia-induced HIF1 transcriptional activation in human U251-HRE cells by luciferase reporter assayMore data for this Ligand-Target Pair
TargetEndothelial PAS domain-containing protein 1/Hypoxia-inducible factor 1-alpha(Homo sapiens (Human))
University of Utah
Curated by ChEMBL
University of Utah
Curated by ChEMBL
Affinity DataEC50: 1.30E+4nMAssay Description:Inhibition of hypoxia-induced HIF1 transcriptional activation in human U251-HRE cells by luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of IL1-induced NFkappaB P65 activation in human osteoarthritic primary chondrocytes preincubated 2 hrs before addition of IL1 by ELISAMore data for this Ligand-Target Pair
Affinity DataEC50: 1.20E+4nMAssay Description:Inhibition of IL1-induced NFkappaB P65 activation in human osteoarthritic primary chondrocytes preincubated 2 hrs before addition of IL1 by ELISAMore data for this Ligand-Target Pair