Compile Data Set for Download or QSAR
Found 443 with Last Name = 'fox' and Initial = 'd'
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057500((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)copy SMILEScopy InChI
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057484((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)copy SMILEScopy InChI
Affinity DataKi:  0.200nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031889((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031897((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)copy SMILEScopy InChI
Affinity DataKi:  0.600nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031880((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  7.80nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Rattus norvegicus)
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | CHEMBL24955 | LY-191704)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Binding affinity on rat 5-alpha reductase-1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031880((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  8nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031877((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  8.80nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057467(4-[4-(4-Methyl-benzoyl)-benzoyl]-benzoic acid | CH...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibitory concentration on human 5alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031892((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039266((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057484((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)copy SMILEScopy InChI
Affinity DataKi:  19nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039259((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039298((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057498(5-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL24...)copy SMILEScopy InChI
Affinity DataKi:  40nMAssay Description:Inhibitory concentration on human 5alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
TargetAlpha-1A adrenergic receptor(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057471(CHEMBL25537 | N-[3-(4,4-Diphenyl-piperidin-1-yl)-p...)copy SMILEScopy InChI
Affinity DataKi:  100nMAssay Description:Binding affinity was tested on human Alpha-1A adrenergic receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039298((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039266((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  150nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031889((1S,9aR,11aS)-6,9a,11a-Trimethyl-7-oxo-2,3,3a,3b,4...)copy SMILEScopy InChI
Affinity DataKi:  160nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039286((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039286((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  180nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039293((1S,9aR,11aS)-9a,11a-Dimethyl-1-(morpholine-4-carb...)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057500((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)copy SMILEScopy InChI
Affinity DataKi:  190nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031892((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  240nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057501((S)-7-Chloro-4a-methyl-3,4,4a,9-tetrahydro-phenant...)copy SMILEScopy InChI
Affinity DataKi:  260nMAssay Description:Binding affinity on human prostatic 5-alpha reductase-2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031897((1S,9aR,11aS)-6-Chloro-9a,11a-dimethyl-7-oxo-2,3,3...)copy SMILEScopy InChI
Affinity DataKi:  490nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039259((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  510nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50031877((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataKi:  1.60E+3nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039293((1S,9aR,11aS)-9a,11a-Dimethyl-1-(morpholine-4-carb...)copy SMILEScopy InChI
Affinity DataKi:  2.20E+3nMAssay Description:Binding affinity for human 5 alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50057498(5-Benzyloxy-1H-indole-2-carboxylic acid | CHEMBL24...)copy SMILEScopy InChI
Affinity DataKi: >2.50E+3nMAssay Description:Inhibitory concentration on human 5-alpha reductase 1 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Rattus norvegicus)
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50368782(Bexlosteride | CHEMBL24955 | LY-191704)copy SMILEScopy InChI
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity on rat 5-alpha reductase-2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
Target3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+4nMAssay Description:Binding affinity for 3-beta-hydroxysteroid dehydrogenaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316640(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.00700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316638(1-(2-ethoxyethyl)-3-ethyl-N7-(4-methylpyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0100nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316647(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0400nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316646(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50318137((R)-3-ethyl-5-(3-methylpiperazin-1-yl)-N-(pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QXDPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316642((1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316651(1-(2-ethoxyethyl)-3-ethyl-N-phenyl-5-(piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316639(5-(4-(aminomethyl)piperidin-1-yl)-1-(2-ethoxyethyl...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316644(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316645(1-(1-(2-ethoxyethyl)-3-ethyl-7-(4-methylpyridin-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316666(1-(2-ethoxyethyl)-3-ethyl-N5-methyl-N5-(1-methylpi...)copy SMILEScopy InChI
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50318144(3-ethyl-N-(4-fluorophenyl)-5-(piperazin-1-yl)-1-(2...)copy SMILEScopy InChI
Affinity DataIC50: 0.0900nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QXDPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50039259((1S,9aR,11aS)-9a,11a-Dimethyl-7-oxo-2,3,3a,3b,4,5,...)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50318136((R)-3-methyl-5-(3-methylpiperazin-1-yl)-N-(pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 0.140nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QXDPubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50318135(3-ethyl-5-(piperazin-1-yl)-N-(pyrimidin-4-yl)-1-(2...)copy SMILEScopy InChI
Affinity DataIC50: 0.150nMAssay Description:Inhibition of PDE5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2QXDPubMed
Target3-oxo-5-alpha-steroid 4-dehydrogenase 2(Homo sapiens (Human))
Pfizer Central Research

Curated by ChEMBL
LigandPNGBDBM50334788((17beta-(N-tert-butylcarbamoyl)-4-aza-5alpha-andro...)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMAssay Description:Binding affinity for human 5-alpha reductase 2 isozymeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W096MNPubMedDrugBank
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Global Research and Development

Curated by ChEMBL
LigandPNGBDBM50316643(1-(1-(2-ethoxyethyl)-3-methyl-7-(4-methylpyridin-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMAssay Description:Inhibition of PDE5 in human platelet by assessed as hydrolysis of [3H]cGMP scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K64K0HPubMed
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