Compile Data Set for Download or QSAR
Found 181 with Last Name = 'lamarre' and Initial = 'd'
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM729((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(2S)-...)copy SMILEScopy InChI
Affinity DataKi:  0.0310nM ΔG°:  -62.4kJ/mole IC50: 4nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM729((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(2S)-...)copy SMILEScopy InChI
Affinity DataKi:  0.130nM ΔG°:  -58.7kJ/mole IC50: 10nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50093010((S)-2-{[(2S,4R)-1-((S)-2-{(S)-2-[(R)-2-((S)-2-Acet...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Compound was evaluated for its binding affinity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S1831TPubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071982((R)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataKi:  600nMAssay Description:Inhibition of hepatitis C virus (HCV) NS3 protease.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50070797(CHEMBL2370476 | Hexapeptide analogue)copy SMILEScopy InChI
Affinity DataKi:  600nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89CX4PubMed
TargetGenome polyprotein/Non-structural protein 4A(Hepatitis C virus)
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50366517(CHEMBL1790303)copy SMILEScopy InChI
Affinity DataKi:  1.40E+4nMAssay Description:The apparent Ki value against NS3-4Apep proteaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z89CX4PubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM748((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM747((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM746((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM745((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1250((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1248((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1249((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1247((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1244((Hydroxyethyl)amidosuccinoyl deriv. 16 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1231((Hydroxyethyl)amidosuccinoyl deriv. 3 | benzyl N-[...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1252((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1251((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S,3R)-...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1245((Hydroxyethyl)amidosuccinoyl deriv. 17 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1250((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1249((2S)-N-[(2S,3R)-4-[(2R)-2-tert-butyl-N-(pentan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM741((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 7nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1246((Hydroxyethyl)amidosuccinoyl deriv. 18 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 8.20nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)copy SMILEScopy InChI
Affinity DataIC50: 8.40nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM743((2S,4R)-N-tert-butyl-1-[(2R,3S)-2-hydroxy-3-[(3-hy...)copy SMILEScopy InChI
Affinity DataIC50: 12nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50137962((1R,2S)-1-((3R,5S)-1-((S)-2-((S)-2-acetamido-2-cyc...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against hepatitis C virus NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52P2SPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50093024(1-{[1-(2-{2-[2-(2-Acetylamino-3-carboxy-propionyla...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S1831TPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1243((Hydroxyethyl)amidosuccinoyl deriv. 15 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1239((Hydroxyethyl)amidosuccinoyl deriv. 11 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 15nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1238((Hydroxyethyl)amidosuccinoyl deriv. 10 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1237((Hydroxyethyl)amidosuccinoyl deriv. 9 | benzyl N-[...)copy SMILEScopy InChI
Affinity DataIC50: 19nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM742((2S,4R)-N-tert-butyl-1-[(2R,3S)-3-[2-(2,6-dimethyl...)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BZ647FPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1232((Hydroxyethyl)amidosuccinoyl deriv. 4 | benzyl N-[...)copy SMILEScopy InChI
Affinity DataIC50: 25nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50093010((S)-2-{[(2S,4R)-1-((S)-2-{(S)-2-[(R)-2-((S)-2-Acet...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibitory activity against NS3 protease complexed with NS4A cofactor peptide (NS3-4A pep)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2S1831TPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071966((R)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetCathepsin B(Homo sapiens (Human))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071966((R)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Compound was tested for inhibition of human liver Cathepsin BMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1248((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 38nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1240((Hydroxyethyl)amidosuccinoyl deriv. 12 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [514-612](Human immunodeficiency virus type 2)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1247((2R)-2-tert-butyl-N-[(2R,3S)-2-hydroxy-3-[(2S)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 42nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1236((Hydroxyethyl)amidosuccinoyl deriv. 8 | benzyl N-[...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1242((Hydroxyethyl)amidosuccinoyl deriv. 14 | benzyl N-...)copy SMILEScopy InChI
Affinity DataIC50: 58nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071973((S)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071973((S)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071966((R)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetChymotrypsin-like elastase family member 1/2A(Sus scrofa (Pig))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071968((S)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of porcine pancreatic elastase (PPE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Boehringer Ingelheim (Canada) Ltd

Curated by ChEMBL
LigandPNGBDBM50071983((S)-3-((S)-2-Acetylamino-3-carboxy-propionylamino)...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Compound was tested for inhibition of human leucocyte elastase (HLE)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2V69HRXPubMed
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Boehringer Ingelheim Pharmaceuticals Inc.

LigandPNGBDBM1229((Hydroxyethyl)amidosuccinoyl deriv. 1 | benzyl N-[...)copy SMILEScopy InChI
Affinity DataIC50: 62nMpH: 5.5 T: 2°CAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Cleavage products and substrate w...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZJWPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50137963((1R,2S)-1-((3R,5S)-1-((S)-2-((S)-2-acetamido-2-cyc...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against hepatitis C virus NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52P2SPubMed
TargetGenome polyprotein(Hepatitis C virus)
Boehringer Ingelheim

Curated by ChEMBL
LigandPNGBDBM50137959(1-{[(R)-(S)-1-[(S)-2-((S)-2-Acetylamino-2-cyclohex...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against hepatitis C virus NS3 proteaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q52P2SPubMed
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