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Found 548 with Last Name = 'majumdar' and Initial = 'd'
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484440(US10934285, Example 24)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350832(CHEMBL1819274)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350831(CHEMBL1819273)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
LigandPNGBDBM50531540(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of MEK in human KYSE-520 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350818(CHEMBL1819257)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484457(US10934285, Example 43)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350827(CHEMBL1819267)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350835(CHEMBL1819272)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350820(CHEMBL1819260)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484469(US10934285, Example 55)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484472(US10934285, Example 59)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484461(US10934285, Example 47)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484466(US10934285, Example 52)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350833(CHEMBL1819275)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350830(CHEMBL1819270)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484421(US10934285, Example 5)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50439791(CHEMBL2419706 | US9181266, 5)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WFBPubMed
TargetProtein Wnt-3a(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50439799(CHEMBL2419698 | US9181266, 13)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of WNT3A signaling in HEK293 cells by luciferase reporter gene assay in presence of forskolinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24Q7WFBPubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350821(CHEMBL1819261)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484467(US10934285, Example 53)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484429(US10934285, Example 13)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350826(CHEMBL1819266)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484422(US10934285, Example 6)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484439(US10934285, Example 23)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484430(US10934285, Example 14)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484419(US10934285, Example 3)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350829(CHEMBL1819269)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484451(US10934285, Example 37)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484426(US10934285, Example 10)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484423(US10934285, Example 7)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350838(CHEMBL1819271)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484470(US10934285, Example 56)copy SMILEScopy InChI
Affinity DataIC50: 6.60nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484418(US10934285, Example 2)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484425(US10934285, Example 9)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
LigandPNGBDBM408067(US10336774, Example 52)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484459(US10934285, Example 45)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484468(US10934285, Example 54)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350824(CHEMBL1819264)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484446(US10934285, Example 32)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484432(US10934285, Example 16)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetGTPase KRas(Homo sapiens (Human))TBA
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human MIA PaCa-2 cells assessed as reduction in p-ERK levelsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484438(US10934285, Example 22)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350828(CHEMBL1819268)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484447(US10934285, Example 33)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484431(US10934285, Example 15)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
LigandPNGBDBM50553790(CHEMBL4763213)copy SMILES
Affinity DataIC50: 10nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CC14BBPubMed
LigandPNGBDBM50553783(Ptpn11 inhibitor tno155 | Shp2 inhibitor tno155 | ...)copy SMILES
Affinity DataIC50: 11nMAssay Description:Allosteric inhibition of 6x-histidine tagged human SHP2 (Met1-L525 residues) expressed in Escherichia coli BL21 Star (DE3) using IRS1_pY1172(dPEG8)pY...More data for this Ligand-Target Pair
TargetHistone deacetylase 1(Homo sapiens (Human))
Novartis Institutes for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50350822(CHEMBL1819262)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N24DWPubMed
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484455(US10934285, Example 41)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
TargetSH2B adapter protein 2(Human)
NOVARTIS AG

US Patent
LigandPNGBDBM484471(US10934285, Example 57)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:The inhibition of SHP2 by compounds of the invention (concentrations varying from 0.003-100 μM) was monitored using an assay in which 0.5 nM of ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2MK6H10US Patent
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