Compile Data Set for Download or QSAR
Found 394 with Last Name = 'perkins' and Initial = 'd'
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099623(4-[2-(4,4-Dimethyl-pent-1-ynyl)-cyclopropyl]-1H-im...)copy SMILEScopy InChI
Affinity DataKi:  0.180nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2QP8PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099622(1-Cyclohexylmethyl-3-[2-(1H-imidazol-4-yl)-cyclopr...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2QP8PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26290(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)am...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26302(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymet...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26301(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(p...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26300(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}qu...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26299(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydrox...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26298(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethy...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26297(CHEMBL215322 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-51.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26296(CHEMBL216053 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26295(CHEMBL214849 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26294(CHEMBL214848 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26291(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(m...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26289(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymet...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26288(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26287(N-(2,3-difluorophenyl)-2-[3-({7-[3-(4-hydroxypiper...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26286(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26285(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2S)-2-(hydrox...)copy SMILEScopy InChI
Affinity DataKi: <1nM ΔG°: <-50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26284(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydrox...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26277(N-(3,5-difluorophenyl)-2-{3-[(7-{3-[4-(hydroxymeth...)copy SMILEScopy InChI
Affinity DataKi:  1nM ΔG°:  -50.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26276(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(hydroxymeth...)copy SMILEScopy InChI
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26274(CHEMBL216769 | N-(3-fluorophenyl)-2-{3-[(7-{3-[4-(...)copy SMILEScopy InChI
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)copy SMILEScopy InChI
Affinity DataKi:  2nM ΔG°:  -49.2kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50071496(CHEMBL73053 | N-(4-Chloro-benzyl)-2-[4-(1H-imidazo...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2QP8PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26278(N-(3-chlorophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)p...)copy SMILEScopy InChI
Affinity DataKi:  8nM ΔG°:  -45.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26282(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)copy SMILEScopy InChI
Affinity DataKi:  9nM ΔG°:  -45.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50050183((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)copy SMILEScopy InChI
Affinity DataKi:  12nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2QP8PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26283(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -44.6kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetHistamine H3 receptor(Rattus norvegicus (rat))
De Novo Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50099624((4-Chloro-phenyl)-acetic acid 3-(1H-imidazol-4-yl)...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Ability to displace [3H]Nalpha-methylhistamine from histamine H3 receptors in homogenates of rat cerebral cortexMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WH2QP8PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26273(N-(2-fluorophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)p...)copy SMILEScopy InChI
Affinity DataKi:  14nM ΔG°:  -44.4kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26272(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)copy SMILEScopy InChI
Affinity DataKi:  18nM ΔG°:  -43.8kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26296(CHEMBL216053 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi:  18nM ΔG°:  -44.2kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26275(N-(4-fluorophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)p...)copy SMILEScopy InChI
Affinity DataKi:  30nM ΔG°:  -42.5kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26285(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2S)-2-(hydrox...)copy SMILEScopy InChI
Affinity DataKi:  39nM ΔG°:  -42.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26280(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)copy SMILEScopy InChI
Affinity DataKi:  39nM ΔG°:  -41.9kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26286(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)copy SMILEScopy InChI
Affinity DataKi:  55nM ΔG°:  -41.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26291(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethyl)(m...)copy SMILEScopy InChI
Affinity DataKi:  65nM ΔG°:  -41.0kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26279(N-(3-cyanophenyl)-2-{3-[(7-{3-[4-(hydroxymethyl)pi...)copy SMILEScopy InChI
Affinity DataKi:  83nM ΔG°:  -40.0kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26295(CHEMBL214849 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi:  87nM ΔG°:  -40.3kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26284(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydrox...)copy SMILEScopy InChI
Affinity DataKi:  94nM ΔG°:  -40.1kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26289(N-(3-fluorophenyl)-2-{3-[(7-{3-[(2R)-2-(hydroxymet...)copy SMILEScopy InChI
Affinity DataKi:  110nM ΔG°:  -39.7kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase B(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26281(2-{3-[(7-{3-[4-(hydroxymethyl)piperidin-1-yl]propo...)copy SMILEScopy InChI
Affinity DataKi:  140nM ΔG°:  -38.7kJ/molepH: 7.5 T: 2°CAssay Description:In vitro kinase assay using recombinant Aurora B bound to INCENP was incubated at room temperature with substrate, and test compounds in the presence...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26297(CHEMBL215322 | N-(2,3-difluorophenyl)-2-{3-[(7-{3-...)copy SMILEScopy InChI
Affinity DataKi:  160nM ΔG°:  -38.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26292(2-{3-[(7-{3-[ethyl(2-hydroxyethyl)amino]propoxy}-6...)copy SMILEScopy InChI
Affinity DataKi:  190nM ΔG°:  -38.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26293(CHEMBL217804 | N-(3-fluorophenyl)-2-{3-[(7-{3-[(2-...)copy SMILEScopy InChI
Affinity DataKi:  220nM ΔG°:  -38.0kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26287(N-(2,3-difluorophenyl)-2-[3-({7-[3-(4-hydroxypiper...)copy SMILEScopy InChI
Affinity DataKi:  220nM ΔG°:  -38.0kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26277(N-(3,5-difluorophenyl)-2-{3-[(7-{3-[4-(hydroxymeth...)copy SMILEScopy InChI
Affinity DataKi:  230nM ΔG°:  -37.9kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26288(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[4-(2-hydroxyet...)copy SMILEScopy InChI
Affinity DataKi:  280nM ΔG°:  -37.4kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
TargetAurora kinase A(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM26298(N-(2,3-difluorophenyl)-2-{3-[(7-{3-[(2-hydroxyethy...)copy SMILEScopy InChI
Affinity DataKi:  350nM ΔG°:  -36.8kJ/moleT: 2°CAssay Description:In vitro kinase assay using recombinant Aurora A purified from Sf9 cells was incubated at room temperature with substrate, and test compounds in the ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GQ6W24PubMed
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