Compile Data Set for Download or QSAR
Found 828 with Last Name = 'roche' and Initial = 'd'
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM29840(spiro-carboxamide scaffold, 13)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065DQPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106090((S)-3-(3,4-Dimethoxy-phenyl)-3-[2-((4-methoxy-buty...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM29839(spiro-carboxamide scaffold, 12)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065DQPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453060(CHEMBL4203893)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106091((S)-3-Benzo[1,3]dioxol-5-yl-3-((S)-4-methyl-2-{2-[...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM29834(spiro-carboxamide scaffold, 7)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065DQPubMed
TargetPeptidyl-prolyl cis-trans isomerase D(Homo sapiens (Human))
Merck Healthcare

Curated by ChEMBL
LigandPNGBDBM50516083(CHEMBL4470490)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CypD (unknown origin) PPIase activity using N-Suc-AAPF-p-nitroanilide as substrate preincubated with enzyme for 10 mins followed by chy...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM2DZ2PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50390701(CHEMBL2070229)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DH5PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106083((S)-3-(4-Methoxy-phenyl)-3-[2-((3-methoxy-propyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453029(CHEMBL4216115)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453944(CHEMBL4217577)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant caspase1 expressed in Escherichia coli using AC-WEHD-AMC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377C96PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50390710(CHEMBL2070319)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DH5PubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453052(CHEMBL4203378)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453053(CHEMBL4213802)copy SMILEScopy InChI
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM29833(spiro-carboxamide scaffold, 6)copy SMILEScopy InChI
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:11beta-HSD1 enzyme activity was assessed in buffer containing a substrate mixture cortisone/NADPH in the presence of test compound. Reaction was init...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X065DQPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50390703(CHEMBL2070231)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DH5PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106086((S)-3-(3,4-Dimethoxy-phenyl)-3-[2-((3-methoxy-prop...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106085((E)-(S)-3-[2-((3-Methoxy-propyl)-{2-[4-(3-o-tolyl-...)copy SMILEScopy InChI
Affinity DataIC50: 7.70nMAssay Description:Inhibition of fluorescent Ramos cell adhesion to VCAM-1 by mouse Very late antigen 4 (VLA-4) integrinMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106085((E)-(S)-3-[2-((3-Methoxy-propyl)-{2-[4-(3-o-tolyl-...)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of fluorescent Ramos cell adhesion to fibronectin by Very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294764(3,3-Dimethyl-pentanedioic acid cyclopropylamide(5-...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294783(3,3-Dimethyl-pentanedioic acid(5-carbamoyl-adamant...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294781(CHEMBL552159 | N-Adamantan-2-yl-4-(3-isopropyl-[1,...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294771(CHEMBL549419 | N-Adamantan-2-yl-2-[1-(isobutylcarb...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294767(CHEMBL562113 | N-Adamantan-2-yl-2-{1-[(2-methoxy-p...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453034(CHEMBL4211859)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of human recombinant caspase-1 using AC-WEHD-AMC as substrate at Km after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FR006XPubMed
LigandPNGBDBM50594790(CHEMBL5200518)copy SMILES
Affinity DataIC50: 10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1B7VPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50390702(CHEMBL2070230)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DH5PubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Merck-Serono

Curated by ChEMBL
LigandPNGBDBM50294783(3,3-Dimethyl-pentanedioic acid(5-carbamoyl-adamant...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of 11beta-HSD1 in mouse liver microsomeMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
TargetCaspase-1(Homo sapiens (Human))
Nestl� Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50453945(CHEMBL4205880)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant caspase1 expressed in Escherichia coli using AC-WEHD-AMC as substrate after 20 mins by fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2377C96PubMed
LigandPNGBDBM50594790(CHEMBL5200518)copy SMILES
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1B7VPubMed
LigandPNGBDBM50594790(CHEMBL5200518)copy SMILES
Affinity DataIC50: 12nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1B7VPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106082((S)-3-[2-((3-Methoxy-propyl)-{2-[4-(3-o-tolyl-urei...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50294780(CHEMBL560849 | N-Adamantan-2-yl-4-(3-cyclopropyl-[...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as cortisol level after 150 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JQ112HPubMed
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Merck-Serono

LigandPNGBDBM50390709(CHEMBL2070318)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant 11beta-HSD1 expressed in Escherichia coli assessed as conversion of cortisone to cortisol level after 150 mins by HTR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z89DH5PubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106086((S)-3-(3,4-Dimethoxy-phenyl)-3-[2-((3-methoxy-prop...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of fluorescent Ramos cell adhesion to fibronectin by Very late antigen 5 (VLA-5)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
LigandPNGBDBM50594797(CHEMBL5195216)copy SMILES
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1B7VPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106082((S)-3-[2-((3-Methoxy-propyl)-{2-[4-(3-o-tolyl-urei...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of fluorescent Ramos cell adhesion to fibronectin by Very late antigen 4 (VLA-4)More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
LigandPNGBDBM50594796(CHEMBL5179655)copy SMILES
Affinity DataIC50: 14nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FN1B7VPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Novartis Institute for Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50106085((E)-(S)-3-[2-((3-Methoxy-propyl)-{2-[4-(3-o-tolyl-...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:In vitro Very late antigen 4 cell adhesion inhibitory activity measured by binding of fluorescently labeled Ramos cells to immobilized VCAM-1.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20001CZPubMed
Displayed 1 to 50 (of 828 total ) | Next | Last >>
Jump to: