Compile Data Set for Download or QSAR
Found 130 with Last Name = 'wensbo' and Initial = 'd'
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataKi:  17.9nMAssay Description:Displacement of [3H]AZD9272 from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataKi:  28nMAssay Description:Displacement of [3H]MPEP from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191127(2-(4-(3-chlorophenyl)but-1-ynyl)-6-methylpyridine ...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0G48PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataIC50: 13.4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataIC50: 14.5nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191139(2-(3-(3,4-dichlorophenoxy)prop-1-ynyl)-6-methylpyr...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481928(CHEMBL1744460)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1544PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50084137(2-Methyl-6-(phenylethynyl)pyridine | 2-Methyl-6-ph...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395942(CHEMBL2164545)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395941(CHEMBL2164546)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Rattus norvegicus (Rat))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395937(CHEMBL2164538)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395943(CHEMBL2164544)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395923(CHEMBL2164550)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481937(CHEMBL1084946)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481931(CHEMBL1077208)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191149(2-methyl-6-(3-(5,6,7,8-tetrahydronaphthalen-2-ylox...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481929(CHEMBL1088617)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50151909(3-(3-Pyridin-2-yl-[1,2,4]oxadiazol-5-yl)-benzonitr...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191116(2-(3-(3-chlorophenylthio)prop-1-ynyl)-6-methylpyri...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0G48PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481936(CHEMBL1084943)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395922(CHEMBL2164552)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481940(CHEMBL1744459)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191124(2-methyl-6-(4-phenylpent-1-ynyl)pyridine | CHEMBL2...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0G48PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481944(CHEMBL1084945)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395940(CHEMBL2164547)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481939(CHEMBL1084944)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481941(CHEMBL1082546)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481935(CHEMBL1744464)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50122758(2-methyl-4-(pyridin-3-ylethynyl)thiazole | 3-(2-(2...)copy SMILEScopy InChI
Affinity DataIC50: 77nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191117(2-methyl-6-(4-phenylbut-1-ynyl)pyridine | CHEMBL21...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0G48PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50182823(4-(3,4-dichlorophenylthio)-2-(5-fluoropyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1544PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481945(CHEMBL1082545)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191146(2-(3-(4-isopropylphenoxy)prop-1-ynyl)-6-methylpyri...)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481938(CHEMBL1087548)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481943(CHEMBL1744463)copy SMILEScopy InChI
Affinity DataIC50: 85nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50182811(4-(3,4-dichlorophenylthio)-2-(pyridin-2-yl)pyrimid...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of glutamate-induced calcium influx in human mGluR5d by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z1544PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191157(2-(3-(3-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)copy SMILEScopy InChI
Affinity DataIC50: 101nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191147(2-(3-(4-chlorophenoxy)prop-1-ynyl)-6-methylpyridin...)copy SMILEScopy InChI
Affinity DataIC50: 102nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191151(2-methyl-6-(3-(p-tolyloxy)prop-1-ynyl)pyridine | C...)copy SMILEScopy InChI
Affinity DataIC50: 115nMAssay Description:Activity at human mGluR5 assessed as effect on glutamate-induced calcium ion mobilization by FLIPRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32WKCPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM38857(2-[5-(3-Chloro-phenyl)-[1,2,4]oxadiazol-3-yl]-pyri...)copy SMILEScopy InChI
Affinity DataIC50: 116nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395929(CHEMBL2164560)copy SMILEScopy InChI
Affinity DataIC50: 118nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50191129(2-(3-(3-chlorophenylthio)but-1-ynyl)-6-methylpyrid...)copy SMILEScopy InChI
Affinity DataIC50: 118nMAssay Description:Activity at human mGluR5d assessed as inhibition of glutamate-induced calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VX0G48PubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481934(CHEMBL1083207)copy SMILEScopy InChI
Affinity DataIC50: 137nMAssay Description:Displacement of [3H]PIB from human amyloid beta (1 to 40) after 30 mins by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67KR6PubMed
TargetMetabotropic glutamate receptor 5(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50395936(CHEMBL2164553)copy SMILEScopy InChI
Affinity DataIC50: 142nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP03WHPubMed
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