Compile Data Set for Download or QSAR
Found 253 with Last Name = 'wickramasinghe' and Initial = 'd'
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 0.00200nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001577(CHEMBL3237712)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001541(CHEMBL3237706)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320340((R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Genentech Inc.

Curated by ChEMBL
LigandPNGBDBM50179795(CHEMBL382690 | PVKRRL-(3-Cl)F-NH2)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of CDK2/CyclinAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DV1JG7PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001583(CHEMBL3237718)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320341((R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001539(CHEMBL3237704 | US8841312, 204)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001576(CHEMBL3237711)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001538(CHEMBL3237703)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001537(CHEMBL3237702 | US8841312, 55)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001536(CHEMBL3237451 | US8841312, 23)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001545(CHEMBL3237710)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001544(CHEMBL3237709)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001543(CHEMBL3237708)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001542(CHEMBL3237707)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001584(CHEMBL3237442 | US8841312, 1)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320339((R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001585(CHEMBL3237443 | US8841312, 57)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM112464(US8623885, 5)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001582(CHEMBL3237717)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001579(CHEMBL3237714)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001535(CHEMBL3237450)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001540(CHEMBL3237705)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001582(CHEMBL3237717)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001540(CHEMBL3237705)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001541(CHEMBL3237706)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001577(CHEMBL3237712)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001578(CHEMBL3237713)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320335((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320345((S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323132((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320342((S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50001586(CHEMBL3237444 | US8841312, 152)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CDK4/cyclin D1 (unknown origin) using Rb as substrate after 60 mins by scintillation counting analysis in presence of [r-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-fused human FLT3 cytoplasmic domain (amino acids 564 to 993) using Ulight-JAK1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BK1DV4PubMed
Displayed 1 to 50 (of 253 total ) | Next | Last >>
Jump to: