Affinity DataIC50: 100nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 260nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 300nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of AKR1C3 (unknown origin) using S-tetralol as substrate in presence of NADP+ by fluorimteryMore data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 310nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of type-1 human steroid 5-alpha-reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 440nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 530nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 540nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 550nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Inhibition of human COX2 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 610nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 940nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 3.48E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C3 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 3.56E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 4.29E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 4.38E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of recombinant N-terminal GST-tagged human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells using S-tetralol as substrat...More data for this Ligand-Target Pair
Affinity DataIC50: 7.35E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C3 His5Gln mutant expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as r...More data for this Ligand-Target Pair
Affinity DataIC50: 8.63E+3nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 8.97E+3nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as reduction in NAD...More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.32E+4nMAssay Description:Antagonistic activity against TP-receptor by inhibition of U 46619-induced contraction of isolated guinea pig tracheaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Thromboxane (TXA2) receptor antagonist activity using human plateletMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of ovine COX1 assessed as reduction in PGF2alpha production by ELISAMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 1.43E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as reduction in NAD...More data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
TargetAldo-keto reductase family 1 member C2(Homo sapiens (Human))
University of Torino
Curated by ChEMBL
University of Torino
Curated by ChEMBL
Affinity DataIC50: 2.68E+4nMAssay Description:Inhibition of N-terminal GST-tagged recombinant human AKR1C2 expressed in Escherichia coli BL21 (DE) Codon Plus RP cells assessed as reduction in NAD...More data for this Ligand-Target Pair