Found 223 with Last Name = 'mcleod' and Initial = 'da' 
Affinity DataKi: 17.9nMAssay Description:Displacement of [3H]AZD9272 from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 28nMAssay Description:Displacement of [3H]MPEP from human mGluR5 expressed in HEK293 cell membranes expressing GLAST after 1 hr by scintillation counterMore data for this Ligand-Target Pair
Affinity DataKi: 4.40E+4nMAssay Description:Compound was evaluated for its inhibitory activity against HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 4.50E+4nMAssay Description:Compound was evaluated for its binding affinity against HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 5.20E+4nMAssay Description:Compound was evaluated for its binding affinity against HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataKi: 8.00E+4nMAssay Description:Compound was evaluated for its binding affinity against HIV-1 proteaseMore data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Negative allosteric modulation of rat recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracellu...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G328V mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
3D Structure (crystal)TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 Q207D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of ALK2 G328V mutant (unknown origin) by radiometric assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK2 R206H mutant using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 R206H mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of ALK2 R258G mutant (unknown origin) by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 13.4nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 14.5nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase receptor R3(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK1 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 G356D mutant (unknown origin) expressed in HEK293 cells incubated for 2 hrs by Na...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD9272 from mGluR5 in Sprague-Dawley rat striatum by autoradiographic analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of DHPG-induced intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Negative allosteric modulation of human recombinant mGluR5 expressed in HEK293 cells expressing GLAST assessed as inhibition of glutamate-stimulated ...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inhibition of human ALK2 using casein as substrate in presence of [gamma-33P]-ATP by radiometric hotspot assayMore data for this Ligand-Target Pair
TargetActivin receptor type-1(Homo sapiens (Human))
Ontario Institute for Cancer Research
Curated by ChEMBL
Ontario Institute for Cancer Research
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Competitive displacement of PBI-6908 from nanoluciferase-fused ALK2 (unknown origin) expressed in HEK293 cells incubated for 2 hrs by NanoBRET NanoGl...More data for this Ligand-Target Pair
