Compile Data Set for Download or QSAR
Found 227 with Last Name = 'tonetti' and Initial = 'da'
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090462(CHEMBL3581693 | US20240043442, Example GDC-0810)copy SMILEScopy InChI
Affinity DataKi:  0.370nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233215(CHEMBL4070169)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)copy SMILEScopy InChI
Affinity DataKi:  0.570nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233203(CHEMBL4098867)copy SMILEScopy InChI
Affinity DataKi:  0.650nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233205(CHEMBL4059888)copy SMILEScopy InChI
Affinity DataKi:  0.730nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233202(CHEMBL4092208)copy SMILEScopy InChI
Affinity DataKi:  1.30nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233204(CHEMBL4094499)copy SMILEScopy InChI
Affinity DataKi:  2nMAssay Description:Displacement of [3H]estradiol from full length recombinant human ESR1 expressed in insect cells by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514279(CHEMBL4527655)copy SMILEScopy InChI
Affinity DataIC50: 0.257nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514280(CHEMBL4586663)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514280(CHEMBL4586663)copy SMILEScopy InChI
Affinity DataIC50: 0.708nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514287(CHEMBL4532671)copy SMILEScopy InChI
Affinity DataIC50: 0.955nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514292(CHEMBL4533964)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514293(CHEMBL4515212)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514283(CHEMBL4524872)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514282(CHEMBL4543096)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514284(CHEMBL4483006)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514287(CHEMBL4532671)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50238741(CHEBI:31638 | Faslodex | Fulvestrant | ICI-182780 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 2 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514281(CHEMBL4516021)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514279(CHEMBL4527655)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514286(CHEMBL4448178)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233216(CHEMBL4081807)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514286(CHEMBL4448178)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514290(CHEMBL4578883)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514285(CHEMBL4436707)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514292(CHEMBL4533964)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233205(CHEMBL4059888)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514282(CHEMBL4543096)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514290(CHEMBL4578883)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233204(CHEMBL4094499)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514293(CHEMBL4515212)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233215(CHEMBL4070169)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514294(CHEMBL4564385)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514289(CHEMBL4538085)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514295(CHEMBL4440649)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514278(CHEMBL4436415)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50539801(CHEMBL4648912 | US11840533, Compound 70)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 1 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514284(CHEMBL4483006)copy SMILEScopy InChI
Affinity DataIC50: 7.40nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514288(CHEMBL4464171)copy SMILEScopy InChI
Affinity DataIC50: 8.10nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50539804(CHEMBL4640025 | US11840533, Compound 71)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 1 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KPPPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50233203(CHEMBL4098867)copy SMILEScopy InChI
Affinity DataIC50: 8.80nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514289(CHEMBL4538085)copy SMILEScopy InChI
Affinity DataIC50: 9.30nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50539802(CHEMBL4647718)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 1 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KPPPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514291(CHEMBL4447374)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of ERalpha in human MCF7:WS8 cells assessed as increase in degradation of ERalpha incubated for 24 hrs by In-Cell Western assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514278(CHEMBL4436415)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50090462(CHEMBL3581693 | US20240043442, Example GDC-0810)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Antagonist activity at ERalpha in tamoxifen-sensitive human MCF7:WS8 cells assessed as inhibition of estradiol-induced response after 18 hrs by lucif...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29P33WBPubMed
TargetProtein kinase C zeta type(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50543625(CHEMBL3732444)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant full-length human aPKCzeta expressed in Sf21 insect cells using 5FAM-ERMRPRKRQGSVRRRV-NH2 as substrate in presence of ATP a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HM5D1SPubMed
TargetEstrogen receptor(Homo sapiens (Human))
University of Illinois College of Pharmacy

Curated by ChEMBL
LigandPNGBDBM50514295(CHEMBL4440649)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity at ERalpha in human MCF7:WS8 cells incubated for 18 hrs by dual luciferase reporter gene assay relative to controlMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2K64NDQPubMed
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Illinois at Chicago

Curated by ChEMBL
LigandPNGBDBM50539800(CHEMBL4632358)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Displacement of APC-labeled biotinylated-avidin from Euphorium-chelated recombinant human BRD4 bromodomain 2 expressed in Escherichia coli preincubat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0KPPPubMed
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