Compile Data Set for Download or QSAR
Found 108 with Last Name = 'mcnulty' and Initial = 'de'
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159507(CHEMBL3785703)copy SMILEScopy InChI
Affinity DataKi:  0.800nMAssay Description:Competitive inhibition of human RIP1 (1 to 375 residues) in presence of increasing ATP by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  1.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  66nMpH: 6.8Assay Description:wild-type HCT116 selected at 6WT-6x the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [A356T](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataKi:  109nMpH: 6.8Assay Description:wild-type HCT116 selected at 3 the IC95More data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.180nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.230nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.310nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.350nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159693(CHEMBL3785482)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of Flag-tagged human RIP1 (1 to 324 residues) after 30 mins by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 0.590nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 0.720nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159508(CHEMBL3786078)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 0.830nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)copy SMILEScopy InChI
Affinity DataIC50: 0.940nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159507(CHEMBL3785703)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159507(CHEMBL3785703)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human WT RIP1 infected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISAMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159699(CHEMBL3787689)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 6.90nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159511(CHEMBL3786162)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36351(CID148124 | Docetaxel)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159507(CHEMBL3785703)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159507(CHEMBL3785703)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human RIP1 in human U937 cells assessed as inhibition of TNF/zVAD.fmk induced necroptosis after 24 hrs by Cell titer-Glo luminescence a...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159512(CHEMBL3786293)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) after 4 hrs by ADP-Glo reagent based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50446278(CHEMBL3109202)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159700(CHEMBL3786660)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Binding affinity to Flag-tagged human RIP1 (1 to 324 residues) at 10 uM after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetKinesin-like protein KIF11(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM36350(6-[4-(Trifluoromethyl)phenyl]-3,4-dihydro-2(1H)-qu...)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 6.8Assay Description:Cell proliferation assay for wild-type cellsMore data for this Ligand-Target Pair
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254432(1-(2-methyl-5-(morpholinosulfonyl)furan-3-yl)-3-ph...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254434(5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50446278(CHEMBL3109202)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of mouse WT RIP1 transfected in HEK293T cells assessed as reduction in S166 phosphorylation by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50446278(CHEMBL3109202)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Binding affinity to mouse RIP1 (1 to 378 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetEndothelial lipase(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254343((S)-1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50159698(CHEMBL3785838)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Binding affinity to human RIP1 (1 to 375 residues) preincubated for 10 mins measured after 20 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4K97PubMed
TargetKinesin-like protein KIF11 [D130V](Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM50220156((R)-N-(3-aminopropyl)-N-(1-(3-benzyl-7-chloro-4-ox...)copy SMILEScopy InChI
Affinity DataIC50: 87.3nMpH: 6.8Assay Description:Cell proliferation assay for ispinesib-resistant DCT116-D130V cellMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PK0DHCPubMed
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254436(5-Methyl-4-(3-phenyl-ureido)-furan-2-sulfonic acid...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254290(1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetEndothelial lipase(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254290(1-(2-methyl-5-(piperidin-1-ylsulfonyl)furan-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254340(1-(4-chlorophenyl)-3-(2-methyl-5-(piperidin-1-ylsu...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetLipoprotein lipase(Rattus norvegicus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254339(1-(4-methoxyphenyl)-3-(2-methyl-5-(piperidin-1-yls...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of Lipoprotein lipase from adipose tissue of ratMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetEndothelial lipase(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254339(1-(4-methoxyphenyl)-3-(2-methyl-5-(piperidin-1-yls...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetEndothelial lipase(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254341(1-(2-chlorophenyl)-3-(2-methyl-5-(piperidin-1-ylsu...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
TargetEndothelial lipase(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50254432(1-(2-methyl-5-(morpholinosulfonyl)furan-3-yl)-3-ph...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02NZPubMed
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